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Kathryn Horwitz and Jennifer Richer; BD; SKB and U Texas Awarded Patents

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Kathryn Horwitz and Jennifer Richer of the University of Colorado Health Sciences Center have been awarded US Patent No. 6,750,015, “Progesterone receptor-regulated gene expression and methods related thereto.”

According to its abstract, the patent discloses expression profiles of genes that are regulated by progesterone receptors, and particularly by progesterone receptor isoforms PR-A and PR-B. Methods for using such genes to identify progesterone receptor agonist and antagonist ligands are described.


Becton Dickinson and Company has been awarded US Patent No. 6,750,457, “System for high-throughput analysis.”

According to its abstract, the patent describes an apparatus and method in which illumination light and collected emitted light share a pathway and subsequently are physically separated. The optical configuration is designed such that at the point of separation, the illumination light has a smaller cross sectional area than the collected light, the abstract states. In addition, collected light is directed away from the pathway of the illumination light and to detection optics. The configuration is adaptable to illumination and light collection across a broad wavelength spectrum, and is adaptable to scanning in a limited depth of field to allow high-throughput optical analysis of samples, the abstract states.


SmithKline Beecham and the University of Texas have been awarded US Patent No. 6,750,026, “Screening methods using ligands of the neutropeptide receptor HFGAN72.

According to its abstract, the patent concerns polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides. Methods of using these polypeptides to diagnose diseases are provided, as well as methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor, the abstract states.

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.