Novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules are provided by the patent, the abstract states. The fluorescent labels of this invention are preferably novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids that may be used in any assay in which radioisotopes, colored dyes, or other fluorescent molecules are currently used. For example, any assay using labeled antibodies, proteins, oligonucleotides, or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays, and diagnostic assays can benefit from use of these compounds.
Inverness Medical Switzerland and Aries Associates Awarded US Patents
Inverness Medical Switzerland has been awarded US Patent 7,317,532, “Flow sensing for determination of assay results.”
The inventors listed on the patent are Stephen Sharrock and Andrew Phelan.
The patent describes an assay result-reading device for use with assays performed using a liquid transport carrier, according to the abstract. The device may include at least one light source capable of emitting light incident upon at least one of two or more spatially separated zones of the carrier, a photodetector positioned to detect light emitted from each of the two said zones and generating signals indicating the presence or absence of a fluid sample in the respective zone, and a computation circuit. The abstract states that the computation circuit may be responsive to the signals and calculate a flow rate for a fluid flowing along the carrier, compare the calculated flow rate to upper and lower limits, and reject the assay result if the calculated flow rate is outside the upper and lower limits.
Aries Associates has been awarded US Patent 7,317,111, “Green and orange fluorescent labels and their uses.”
The inventors listed on the patent are Ram Bhatt, Michael Conrad, Azzouz Bencheikh, and Yifeng Xiong.