Skip to main content
Premium Trial:

Request an Annual Quote

Guava Technologies

Premium
Guava Technologies has launched its Guava Nexin assay, the company announced this week.  
 
The newly revised assay, for the first time, provides all necessary reagent components in a single cocktail, the company said. The newly reformulated Guava Nexin reagent eliminates the need for pre-assay dilutions, cocktail preparations, or time consuming wash steps. The assay protocol is identical for use on all Guava systems, using both tube- and plate-based approaches. 
 
The new mix-and-read Guava Nexin assay relies on a two-dye strategy. The assay uses Annexin V-PE to detect the translocation of phosphatidylserine to the external surface of the membrane of apoptotic cells. The assay incorporates this PS-Annexin V-PE binding as an indicator of early-stage apoptotic cells. The cell impermeant dye 7-AAD is included in the Guava Nexin reagent as an indicator of membrane structural integrity.
 
7-AAD is excluded from live healthy cells and early apoptotic cells, but permeates late stage apoptotic and dead cells. In conjunction, the two dyes, added in one step as a reagent cocktail, provide quick and accurate determination of early- and late-stage cellular apoptosis, the company said.

The Scan

Purnell Choppin Dies

Purnell Choppin, a virologist who led the Howard Hughes Medical Institute, has died at 91, according to the Washington Post.

Effectiveness May Decline, Data From Israel Suggests

The New York Times reports that new Israeli data suggests a decline in Pfizer-BioNTech SARS-CoV-2 vaccine effectiveness against Delta variant infection, though protection against severe disease remains high.

To See Future Risk

Slate looks into the use of polygenic risk scores in embryo screening.

PLOS Papers on Methicillin-Resistant Staphylococcus, Bone Marrow Smear Sequencing, More

In PLOS this week: genomic analysis of methicillin-resistant Staphylococcus pseudintermedius, archived bone marrow sequencing, and more.