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Geron, Applied Precision Awarded US Patents

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Geron has been awarded US Patent 7,410,798, “Culture system for rapid expansion of human embryonic stem cells.”
 
The inventors listed on the patent are Ramkumar Mandalam, Chunhui Xu, Joseph Gold, and Melissa Carpenter.
 
The patent provides an improved system for culturing human pluripotent stem cells, according to its abstract. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells. In the system described in the patent, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to the method described in the patent causes the cells to expand rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows for bulk proliferation of pPS cells for commercial production of important products for use in drug screening and human therapy.
 

 
Applied Precision has been awarded US Patent 7,408,176, “System and method employing photokinetic techniques in cell biology imaging applications.”
 
The inventors listed on the patent are Paul Goodwin, Carl Brown, and Steven Reese.
 
As stated in the abstract, the patent describes a system and method using photokinetic techniques in cell biology imaging applications. These systems and methods may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more analyses of interest. Various methodologies and applications may include selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

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