Skip to main content
Premium Trial:

Request an Annual Quote

Geron, Applied Precision Awarded US Patents

Premium
Geron has been awarded US Patent 7,410,798, “Culture system for rapid expansion of human embryonic stem cells.”
 
The inventors listed on the patent are Ramkumar Mandalam, Chunhui Xu, Joseph Gold, and Melissa Carpenter.
 
The patent provides an improved system for culturing human pluripotent stem cells, according to its abstract. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells. In the system described in the patent, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to the method described in the patent causes the cells to expand rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows for bulk proliferation of pPS cells for commercial production of important products for use in drug screening and human therapy.
 

 
Applied Precision has been awarded US Patent 7,408,176, “System and method employing photokinetic techniques in cell biology imaging applications.”
 
The inventors listed on the patent are Paul Goodwin, Carl Brown, and Steven Reese.
 
As stated in the abstract, the patent describes a system and method using photokinetic techniques in cell biology imaging applications. These systems and methods may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more analyses of interest. Various methodologies and applications may include selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.