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Geron and Biolex Therapeutics Awarded US Patents

Geron has been awarded US Patent 7,326,572, “Endoderm cells from human embryonic stem cells.”
The inventors listed on the patent are Gregory Fisk and Margaret Inokuma.
The patent describes a system for producing pancreatic islet cells from embryonic stem cells, according to the abstract. Differentiation is initiated towards endoderm cells, and focused using reagents that promote the emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research, drug screening, or regenerative medicine.

Biolex Therapeutics has been awarded US Patent 7,326,385, “Plate and method for high throughput screening.”
The inventor listed on the patent is Keith Everett.
A multiwell plate and method for media exchange is provided by the patent, the abstract stated. The cell wells are each connected via a channel to one of several aspiration holes. The wells contain a porous, hydrophilic frit, which is suspended on a ledge above a reservoir of fluid media and supports a tissue sample. The frit wicks the fluid media upwards to supply the tissue sample with nutrients. Old media is aspirated from the wells by a liquid handling device which inserts a pipette tip into the aspiration holes. The pipette tip suctions the media out of the cell well, through the channel, into the aspiration hole, and out through the pipette tip. New media is dispersed through the pipette tip and directly into the cell well.

The Scan

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Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

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