The General Hospital Corporation has been awarded US Patent 7,291,454, “Transgenic animals and cell lines for screening drugs effective for the treatment or prevention of Alzheimer's disease.”
Inventors listed on the patent are Suzanne de la Monte and Jack Wands.
The patent describes transgenic animals and transfected cell lines expressing a protein associated with Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas, according to its abstract. The invention also describes the use of such transgenic animals and transfected cell lines to screen potential drug candidates for treating or preventing Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. The patent relates to new antisense oligonucleotides, ribozymes, triplex-forming DNA, and external guide sequences that can be used to treat or prevent Alzheimer's disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas.