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GE Healthcare, EMC, Carl Zeiss, ThermoFisher Cellomics, Promega

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GE Healthcare this week presented a preview of its new IN Cell Miner software for the management of data generated by cellular high content analysis and screening at the CHI High Content Analysis meeting in San Francisco, Calif., the company said.
 
The software will be available later this year and was developed in collaboration with EMC. The system is based on EMC’s electronic content management system, EMC Documentum OEM edition, and handles data that have been generated by GE Healthcare’s IN Cell Analyzer and similar systems.
 
As part the company’s relationship with EMC, GE Healthcare has also joined the EMC Documentum application developer program. As a member, GE Healthcare receives specialized design consultation and guidance, along with access to dedicated Documentum technical resources, to ensure that GE Healthcare’s solution meets the highest quality standards. 
 

 
Carl Zeiss this week introduced the Zeiss Incubation System for the Axio Observer and Axiovert 200 inverted research microscopes, the company said.
 
According to the manufacturer, the ZEISS Incubation System consists of a series of stackable components that allow the independent control of temperature, humidity, and pH, CO2, and O2 concentration.
 
The company also said that the system’s modular design makes it easy to set up and permits flexible expansion and future upgrades. 
 
The environmental parameters within the system are controlled with Zeiss AxioVision software, and all actual incubation parameters are recorded and saved with the image files. 
 

 
ThermoFisher Cellomics launched several products this week at High-Content Analysis 2008 in San Francisco: a cell-imaging workstation that provides table top automation for high-content screening, with applications in live-cell assays and post-assay processing; an [optional] liquid-handling module that adds fully-automated pipetting to the ArrayScan VTI and is fully integrated with the ArrayScan software and hardware; an [optional] emission filter wheel that allows use of a wider variety of filters on the ArrayScan VTI and provides greater flexibility in using fluorescent probes; a 2.5x [optional] objective that the company said is especially useful for tissues, whole organisms such as zebrafish and C. elegans, and whole-well reads; the Neuronal Profiling v3.5 BioApplication image analysis module that features added measurements of synaptagenesis in both cultured and primary neuronal cell cultures; and a Co-Localization BioApplication image analysis module that measures areas where fluorescent labels coincide within a sample.
 
The company also launched upgrades of all the software for the ThermoFisher Cellomics high-content analysis platform, instrument software usability enhancements, improved visualization software, upgrades to all BioApplication modules, a Montage tool for analyzing large tiled images, a new HCSExplorer Web-based data mining tool, and improved integration with Spotfire and GeneData screener through HCSExplorer.  
 
The company introduced additional Cellomics HCA reagent kits and CryoRedi GFP cell lines at the meeting as well.
 

 
Promega has expanded its bioluminescent caspase assay offerings with the release of Caspase-Glo 2 and 6 assays, the company announced this week.
 
The Caspase-Glo 2 and 6 Assay homogenous protocols allow for both high-throughput or single-sample analysis. The protocols consist of a single-step-reagent addition of an optimized lysis/activity buffer and the Promega Ultra-Glo recombinant luciferase. In the presence of caspase, the substrate is cleaved, releasing aminoluciferin which is consumed by luciferase, resulting in a "glow-type" luminescent signal that is proportional to caspase activity.