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Evotec Technologies and Surface Logix Among Recent US Patent Winners

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Evotec Technologies has been awarded US Patent No. 6,841,356, “Processes for cell traced based testing of biological cells.”

Inventors listed on the patent are Gunter Fuhr, Rolf Hagedorn, Stephen Graham Shirley, and Ekkehard Richter.

According to its abstract, the patent protects processes for the cell trace-based testing of biological cells, wherein the cells are applied to an at least partially structured and/or surface-modified substrate and move adhesively over surface track regions of the substrate while producing cell traces consisting of material residues separated from the cells, and cell tests are performed on the cell traces. A process for cell cultivation on biocompatible modified substrates whose surfaces are covered by cell traces is also described, the abstract states.


Active Motif and Centre National de la Recherche Scientifique have been awarded US Patent No. 6,841,535, “Peptide-mediated transfection agents and methods of use.”

Inventors listed on the patent are Gilles Divita, May Morris, Jean Mery, Frederic Heitz, Joseph Fernandez, John Archdeacon, and Kyle Horndorp.

According to its abstract, the patent protects peptides that are useful as transfection agents. The peptides can facilitate the efficient cellular internalization of a broad range and size of compounds that when non-covalently complexed therewith are efficiently internalized into a cell, the abstract states. Advantages include, but are not limited to excellent transfection efficiency; relatively low toxicity; internalization by a broad host-cell spectrum; and the simplicity and cost-effectiveness that arise from not having to covalently complex the peptide with a specific molecule to be delivered, the abstract states. Applications include, but are not limited to the delivery of diagnostics and therapeutics; drug discovery; gene discovery; and the analysis and/or manipulation of other cellular and molecular biological functions, the abstract states.


The University of California has been awarded US Patent No. 6,844,150, “Ultrahigh resolution multicolor colocalization of single fluorescent probes.”

Inventors listed on the patent are Shimon Weiss, Xavier Michalet, and Thilo Lacoste.

According to its abstract, the patent protects a novel optical ruler based on ultrahigh-resolution co-localization of single fluorescent probes. Two unique families of fluorophores are used, namely energy-transfer fluorescent beads and semiconductor nanocrystal quantum dots, that can be excited by a single laser wavelength but emit at different wavelengths. A novel multicolor sample-scanning confocal microscope was constructed which allows one to image each fluorescent light emitter, free of chromatic aberrations, by scanning the sample with nanometer scale steps using a piezo-scanner. The resulting spots are accurately localized by fitting them to the known shape of the excitation point-spread-function of the microscope, the abstract states.


Surface Logix has been awarded US Patent No. 6,844,184, “Device for arraying biomolecules and for monitoring cell motility in real-time.”

Inventors listed on the patent are Enoch Kim, Gregory Kirk, Olivier Schueller, and Emanuele Ostuni.

According to its abstract, the patent protects devices for arraying biomolecules, including cells, methods for arraying biomolecules, assays for monitoring cellular movement, and systems for monitoring cellular movement. The devices include a support; a first layer placed in fluid-tight contact with the support, the first layer having an upper surface and defining a pattern of micro-orifices … such that the walls of each micro-orifice and the micro-region on the support together define a micro-well; and a second layer configured to be placed in fluid-tight contact with the upper surface of the first layer, the second layer defining a pattern of macro-orifices, et cetera … such that the walls of the macro-orifice and the macro-region together define a macro-well, the abstract states.

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