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Essen Instruments, Caliper, and Invitrogen Are Among Recent US Patent Winners

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Essen Instruments has been issued US Patent No. 7,067,046, "System for rapid chemical activation in high-throughput electrophysiological measurements."

Kirk Schroeder is the sole inventor listed on the patent.

According to its abstract, the patent protects the addition of an ultraviolet light source to a high-throughput electrophysiological measurement system to allow for rapid chemical stimulation via caged compound release to a plurality of measurement samples. The integrated electrophysiological measurement system includes a computer-controlled data collection system, an integrated electronics head for making parallel electrical measurements, and an integrated fluidics head used in part to transfer test compounds into the measurement process. This light source, and associated light coupling to a plurality of test samples, is used in conjunction with the system to make effectuate high-throughput electrical measurements with respect to fast-acting, chemically-activated electrophysiological events. The UV-source modification allows for rapid stimulation and measurement of multiple fast ligand-gated ion channel events in parallel, the abstract states.


The University of Rochester has been awarded US Patent No. 7,067,251, "Methods of directly selecting cells expressing inserts of interest."

Inventors listed on the patent are Maurice Zauderer and Ernest Smith.

According to its abstract, the patent protects a high-efficiency method of introducing DNA and producing libraries in linear DNA viruses such as poxvirus, and methods of selecting polynucleotides of interest based on cell non-viability or other phenotypes.


Warner-Lambert has been awarded US Patent No. 7,067,262, "Cell line for the expression of an α2δ2 calcium channel subunit and methods of use."

Ti-Zhi Su is the sole inventor listed on the patent.

According to its abstract, the patent protects a method for determining the binding ability of a compound to bind to an α2δ2 subunit of a calcium channel. The method comprises providing an α2δ2 subunit of a calcium channel, contacting the subunit with the compound, and determining the binding ability of the compound to bind to the subunit.


Caliper Life Sciences has been awarded US Patent No. 7,067,263, "High-throughput screening assay systems in microscale fluidic devices."

Inventors listed on the patent are Wallace Parce, Anne Kopf-Sill, and Luc Bousse.

According to its abstract, the patent protects novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.


H. Lundbeck has been awarded US Patent No. 7,067,277, "Chimeric G proteins and uses thereof."

Inventors listed on the patent are Kenneth Jones, Mary Walker, Joseph Tamm, Theresa Brancheck, and Christophe Gerald.

According to its abstract, the patent protects isolated nucleic acids encoding chimeric G proteins; vectors comprising nucleic acids encoding chimeric G proteins; cells comprising such vectors; processes of determining agonists and antagonists of mammalian G protein-coupled receptors utilizing chimeric G proteins; processes of determining compounds which bind to mammalian G protein-coupled receptors utilizing chimeric G proteins; processes for making a composition of matter which specifically binds to a mammalian G protein-coupled receptor utilizing chimeric G proteins; processes of identifying a ligand for a mammalian G protein-coupled receptor utilizing chimeric G proteins, and processes of screening a plurality of independent clones to identify and isolate a clone encoding a mammalian G protein-coupled receptor utilizing chimeric G proteins.


Harvard College has been awarded US Patent No. 7,067,306, "Device containing cytophilic islands that adhere cells separated by cytophobic regions."

Inventors listed on the patent are Rahul Singhvi, Amit Kumar, George Whitesides, Donald Ingber, Gabriel Lopez, Daniel Wang, and Gregory Stephanopoulos.

According to its abstract, the patent protects a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands on which cells adhere, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The cytophilic islands, cytophobic regions, or both may be formed of a self-assembled monolayer, the abstract states.


Invitrogen has been awarded US Patent No. 7,067,324, "Photon reducing agents for fluorescence assays."

Inventors listed on the patent are Tom Knapp, Gregor Zolkarnik, Paul Negulescu, Roger Tsein, and Tim Rink.

According to its abstract, the patent protects a method for reducing undesirable light emission from a sample using at least one photon producing agent and at least one photon reducing agent (e.g. dye-based photon reducing agents). The patent also describes a method for reducing undesirable light emission from a sample, such as a biochemical or cellular sample, with at least one photon producing agent and at least one collisional quencher. The patent also describes a method for reducing undesirable light emission from a sample with at least one photon producing agent and at least one quencher, such as an electronic quencher. The patent also describes a system and method of screening test chemicals in fluorescent assays using photon reducing agents, and describes compositions, pharmaceutical compositions, and kits for practicing these methods.

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