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DNAVEC Research, Tanabe Seiyaku Company, University of South Florida, and University of Chile Awarded US Patents

DNAVEC Research and Tanabe Seiyaku Company have been awarded US Patent 7,323,337, “Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors.”
Inventors listed on the patent are Yutaka Hanazono, Yasuji Ueda, Yasushi Kondo, and Yutaka Suzuki.
The patent provides simian immunodeficiency virus vectors for gene transfer to primate embryonic stem cells, the abstract said. The method for gene transfer to primate ES cells using the vectors described in the patent is useful in, for example, research into embryology and disease, clinical applications, and experimental models for primates. The method is also useful in assaying and screening for genes and reagents which are able to enhance the specific differentiation of tissues or cells, and are useful in preparing desired cells or tissues differentiated from ES cells.

The University of South Florida and the University of Chile have been awarded US Patent 7,323,333, “Materials and methods for regulating process formation in cell culture.”
The inventors listed on the patent are Pablo Caviedes, Raul Caviedes, Thomas Freeman, Juan Asenjo, Barbara Andrews, Dario Sep lveda, Christian Arriagada, and Julio Rivera.
According to the abstract, the patent pertains to materials and methods for inhibiting process formation and extension by cells in culture. In addition, the patent describes cultures of process-forming cells wherein formation and extension of processes have been inhibited. The patent also provides methods of transplantation using process-forming cells that have been cultured by these process-inhibiting methods.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

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Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

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LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.