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Definiens, Surface Logix, and Vertex Pharma Among Recent US Patent Winners

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Definiens of Munich, Germany, has been awarded US Patent No. 7,146,380, “Extracting information from input data using a semantic cognition network.”
 
Inventors listed on the patent are Arno Schaepe, Maria Athelogou, Ursula Benz, Christof Krug, and Gerd Binning.
 
According to its abstract, the patent protects a method for extracting information from input data comprising mapping of the input data into a data object network. The method uses a semantic cognition network comprised of the data object network, a class object network, and a processing object network. The semantic cognition network uses a set of algorithms to process the semantic units. The semantic cognition network defines a processing object in the processing object network by selecting a data domain in the data object network, a class domain in the class object network, and an algorithm from the set of algorithms. The processing object comprises the data domain, the class domain, and the algorithm; and is used in the processing object network to process the semantic units, the abstract states. The method finds use in applications including but not limited to processing image data, topological data, audio data, or text data, the patent states.
 

 
The National Jewish Medical and Research Center in Denver, Col., has been awarded US Patent No. 7,169,570, “Method to identify regulators of cellular activation using Bcl10.”
 
Inventors listed on the patent are Brian Schaefer, Philippa Marrack, and John Kappler.
 
According to its abstract, the patent protects methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates activation of Bcl10-mediated signal transduction. These methods utilize the discovery of the activation-dependent formation of Bcl10 aggregates in a cell, the abstract states.
 

 
Surface Logix of Brighton, Mass., has been awarded US Patent Nos. 7,169,577 and 7,169,578, both entitled “Cell isolation screening device and method of using same.”
 
Inventors listed on the patents are Evelyn Wang, Rocco Casagrande, Amar Kendale, Enoch Kim, Emanuele Ostuni, and Olivier Schueller.
 
According to their abstracts, the patents protect methods and devices for screening a single cell or a small group of cells for a desired biological activity. In particular, the patents describe methods for delivering a cell or cells to a plurality of cell-isolation regions of a cell-isolation device, transferring the cells to a plurality of wells of a cell-expansion device, and detecting the potential desired biological activity of the cells. Each of the cell-isolation regions comprise a bioaffinity region capable of binding a single cell or small group of cells through the use of bioaffinity ligands immobilized in the cell isolation regions. Preferably, the wells of the cell expansion device encompass a cavity that provides sufficient volume for cell proliferation, the abstracts state.
 

 
Vertex Pharmaceuticals of Cambridge, Mass., has been awarded US Patent No. 7,169,609, “Multiwell plate assembly for use in high-throughput assays.”
 
Inventors listed on the patent are Paul Negulescu, Alec Harootunian, Philip Salzmann, Javier Flores, James Sinclair, Minh Vuong, Ashvani Singh, and Fred VanGoor.
 
According to its abstract, the patent protects a device for characterizing the biological properties of cells that includes a plurality of dual-compartment assay chambers, wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer, the abstract states.