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CytoTools, Carnegie Mellon, and Amnis Recently Awarded US Patents

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CytoTools has been awarded US Patent No. 7,008,773, "Method for identifying anti-apoptosis compounds."

Inventors listed on the patent are Mark Freyberg, Peter Friedl, and Dirk Kaiser.

According to its abstract, the patent protects a method for identifying substances with anti-apoptotic activity, where (i) cells which express both IAP and the integrin &alphavß3 are cultured; (ii) the cells are caused to produce an apoptosis-inducing substance, and/or a substance or substances which induces/induce apoptosis is/are added; (iii) the test substance is added; (iv) the apoptosis rate is measured.


Carnegie Mellon University has been awarded US Patent No. 7,008,798, "Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods."

Alan Waggoner is the sole inventor listed on the patent.

According to its abstract, the patent protects luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by luminescence detection methods. The dyes are cyanine and cyanine-type dyes that contain or are derivatized to contain a reactive group. The reactive group is covalently reactive with amine, hydroxyl, and/or sulfhydryl groups on the component so that the dye can be covalently bound to the component. In addition, the dyes are preferably soluble in aqueous or other medium in which the component is contained. The components to be labeled can be either biological materials, such as antibodies, antigens, peptides, nucleotides, hormones, drugs; or non-biological materials, such as polymers, glass, or other surfaces. Any luminescent or light-absorbing detecting step can be employed in the method of the invention, the abstract states.


Amnis has been awarded US Patent No. 7,009,651, "System and method for high numeric aperture imaging systems."

Inventors listed on the patent are William Ortyn, David Basiji, and David Perry.

According to its abstract, the patent protects a system and method for high numeric aperture imaging systems that include a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the portions are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved, the abstract states.

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