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CytoTools, Carnegie Mellon, and Amnis Recently Awarded US Patents


CytoTools has been awarded US Patent No. 7,008,773, "Method for identifying anti-apoptosis compounds."

Inventors listed on the patent are Mark Freyberg, Peter Friedl, and Dirk Kaiser.

According to its abstract, the patent protects a method for identifying substances with anti-apoptotic activity, where (i) cells which express both IAP and the integrin &alphavß3 are cultured; (ii) the cells are caused to produce an apoptosis-inducing substance, and/or a substance or substances which induces/induce apoptosis is/are added; (iii) the test substance is added; (iv) the apoptosis rate is measured.

Carnegie Mellon University has been awarded US Patent No. 7,008,798, "Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods."

Alan Waggoner is the sole inventor listed on the patent.

According to its abstract, the patent protects luminescent dyes and methods for covalently attaching the dyes to a component or mixture of components so that the components may be detected and/or quantified by luminescence detection methods. The dyes are cyanine and cyanine-type dyes that contain or are derivatized to contain a reactive group. The reactive group is covalently reactive with amine, hydroxyl, and/or sulfhydryl groups on the component so that the dye can be covalently bound to the component. In addition, the dyes are preferably soluble in aqueous or other medium in which the component is contained. The components to be labeled can be either biological materials, such as antibodies, antigens, peptides, nucleotides, hormones, drugs; or non-biological materials, such as polymers, glass, or other surfaces. Any luminescent or light-absorbing detecting step can be employed in the method of the invention, the abstract states.

Amnis has been awarded US Patent No. 7,009,651, "System and method for high numeric aperture imaging systems."

Inventors listed on the patent are William Ortyn, David Basiji, and David Perry.

According to its abstract, the patent protects a system and method for high numeric aperture imaging systems that include a splitter, a defocusing system, and a combiner. The splitter reflects a portion of collected light and transmits another portion of the collected light. The defocusing system is configured to modify optical power of either the transmitted portion or reflected portion of the collected light. The combiner is oriented with respect to a mechanical angle. The combiner recombines portions of the transmitted portion and the reflected portion such that the portions are subsequently transmitted being separated by an optical separation angle based upon the mechanical angle of orientation of the combiner. Various other implementations are used to maintain focus with regards to the imaging systems involved, the abstract states.

The Scan

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.

Clinical Genomic Lab Survey Looks at Workforce Needs

Investigators use a survey approach in Genetics in Medicine Open to assess technologist applications, retention, and workforce gaps at molecular genetics and clinical cytogenetics labs in the US.

Study Considers Gene Regulatory Features Available by Sequence-Based Modeling

Investigators in Genome Biology set sequence-based models against observational and perturbation assay data, finding distal enhancer models lag behind promoter predictions.

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.