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Corning, Euroscreen, and Clarient Recently Awarded US Patents


Corning has been awarded US Patent No. 6,943,009, "Multi-well assembly for growing cultures in vitro."

Inventors listed on the patent are William Lacey, Gregory Mathus, David Root, and John Ryan.

According to its abstract, the patent protects a high-throughput cell or tissue culture apparatus, which is configurable to an industry-standard well plate format. The apparatus comprises a number of vessels, which may be suspended in wells of a plate. Each vessel has at least one sidewall defining a first opening and a second opening, each of predetermined cross-sectional area. The second opening has an inner cross-sectional area greater than either the inner cross-sectional area of the first opening or a cross-sectional area in a horizontal plane between the first and second openings. A relatively large substrate area is provided in each vessel for supporting tissue cultures in a fluid medium, the abstract states.

Euroscreen has been awarded US Patent No. 6,946,244, "Methods of identifying a ligand, an agonist, and an antagonist of G-protein coupled receptor GPR86 (P2Y13)."

Inventors listed on the patent are Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillion, Vincent Lannoy, Marc Parmentier, and Jean-Marie Boeynaems.

According to its abstract, the patent protects a recombinant cell expressing a nucleotide sequence encoding a G-protein coupled receptor having an amino acid sequence which presents more than 70-percent sequence identity with the nucleotide sequence of GPR86 (P2Y13), as well as to a drug-screening method and kit using the orphan G-protein coupled receptor GPR86, the corresponding polynucleotide, and said recombinant cell to identify agonist, inverse agonist, and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.

Clarient has been awarded US Patent No. 6,947,583, "Histological reconstruction and automated image analysis."

Inventors listed on the patent are Bob Ellis, William Decker, and Gina McLaren.

According to its abstract, the patent protects a method for automated image analysis of a biological specimen by histological reconstruction. The patent also protects an automated cell imaging method for analyzing a biological specimen that has consecutively been stained by an in situ hybridization method, an immunohistochemistry method, or a nucleic acid stain; and counterstained. The method couples composite images in an automated manner for processing and analysis. To identify structure in tissue that cannot be captured in a single field of view image or a single staining technique, the disclosure provides a method for histological reconstruction to analyze many fields of view on potentially many slides simultaneously, the abstract states.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.