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Corning and Molecular Devices Awarded US Patents

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Corning has been awarded US Patent 7,332,328, “Microcolumn-platform based array for high-throughput analysis.”
 
The inventors listed on the patent are Brian Webb, Jinlin Peng, Michael Brady, Mircea Despa, Keith Horn, Joydeep Lahiri, David Root, James Stamatoff, and Po Ki Yuen.
 
The patent provides a device and methods for performing biological or chemical analyses, according to the abstract. The device includes an array of three-dimensional microcolumns projecting away from a support plate. As described in the abstract, each microcolumn has a relatively planar, first surface remote from the support plate. An array of multiple, different biological materials may be attached to the first surface. The device, when used in combination with microtiter well plates, can improve the efficiency of high-throughput binding assays that use microarrays.
 

 
Molecular Devices has been awarded US Patent 7,332,292, “Constitutively translocating cell line.”
 
The inventors listed on the patent are Robert Oakley and Christine Hudson.
 
The patent relates to agonist-independent methods of screening for compounds that alter GPCR desensitization, its abstract said. Included in the invention are cell lines containing GPCR kinases, in which GPCRs are desensitized in the absence of agonist; the GPCR kinases may be modified. The patent also describes methods to determine if a GPCR is expressed at the plasma membrane, and if the GPCR has an affinity for arrestin. Modified GPCRs that have increased arrestin affinity are included in the patent. These modified GPCRs can be used to screen for compounds that alter desensitization, including both the agonist-independent methods and agonist-dependent methods described in the patent.

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