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Compound Therapeutics, Whitehead, and Scripps Among Recent US Patent Winners

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Compound Therapeutics has been awarded US Patent No. 6,951,725, "In vitro protein interaction detection systems."

Inventors listed on the patent are Markus Kurz and Peter Lohse.

According to its abstract, the patent protects in vitro assays for the identification of interactions between proteins or other molecules, the identification of transcriptional activator proteins, and the detection of compounds that inhibit protein/protein or protein/compound interactions. The patent also protects in vitro assays for the selection of interacting proteins and transcriptional activator proteins out of libraries, the abstract states.


The Whitehead Institute for Biomedical Research has been awarded US Patent No. 6,951,757, "Transfection methods and uses related thereto."

David Sabatini is the lone inventors listed on the patent.

According to its abstract, the patent protects a method of introducing nucleic acid molecules into eukaryotic cells by (a) depositing a nucleic acid molecule-containing mixture onto a surface; (b) affixing the nucleic acid molecule-containing mixture to the surface; and (c) plating eukaryotic cells onto the surface under appropriate conditions for entry of the nucleic acid molecules into the cells.


The Scripps Research Institute has been awarded US Patent No. 6,951,947, "Labeled peptides, proteins, and antibodies, and processes and intermediates useful for their preparation."

Inventors listed on the patent are Klaus Hahn and Alexei Toutchkine.

According to its abstract, the patent protects peptide synthons having protected functional groups for attachment of desired moieties (e.g. functional molecules or probes). The patent also protects peptide conjugates prepared from such synthons, and synthon and conjugate preparation methods including procedures for identifying the optimum probe attachment site, the abstract states. The patent also provides examples of biosensors having environmentally sensitive dyes that can locate specific biomolecules within living cells and detect chemical and physiological changes in those biomolecules as the living cell is moving, metabolizing, and reacting to its environment. The patent also gives examples for detecting GTP activation of a Rho GTPase protein using polypeptide biosensors. When the biosensor binds GTP-activated Rho GTPase protein, the environmentally sensitive dye emits a signal of a different lifetime, intensity, or wavelength than when not bound. Lastly, the patent describes new fluorophores whose fluorescence responds to environmental changes, that have improved detection and attachment properties, and that can be used in living cells, or in vitro, the abstract states.

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