Skip to main content
Premium Trial:

Request an Annual Quote

Columbia University, Vital Therapies Awarded US Patents

Columbia University has been awarded US Patent 7,390,659, “Methods for inducing differentiation of embryonic stem cells and uses thereof.”
The inventors listed on the patent are Thomas Jessell, Hynek Wichterle, and Ivo Lieberam.
According to its abstract, the patent provides a method for inducing the differentiation of an embryonic stem cell into a differentiated neural cell. The patent also describes a method for producing differentiated neural cells, and a population of cells comprising the differentiated neural cells. The patent discusses neural progenitor cells, differentiated neural cells, and their use. As stated in the abstract, the patent describes a method for isolating a population of differentiated neural cells. Finally, the patent provides a method for identifying an agent for use in treating a condition associated with neuron degeneration.

Vital Therapies has been awarded US Patent 7,390,651, “C3A serum-free clonal cell line and methods of use.”
The inventors listed on the patent are Dennis Triglia and Anthony Purchio.
The patent describes a serum-free C3A clonal cell line and methods for generating the cell line, as stated in its abstract. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from which it is derived. Methods using the serum-free C3A clonal cell line for the production, expression, and recovery of harvestable polypeptides, screening compounds for metabolic activity, studying enteric disease, and for use in an artificial liver device are also provided.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.