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Chempaq and Phylogency Among Recent US Patent Winners


Ruy Tchao has been awarded US Patent No. RE 38,863, a re-issue of US Patent No. 05601997, "Chemotaxis assay procedure."

Tchao, a professor of pharmacology and toxicology at the University of the Sciences in Philadelphia, is the lone inventor listed on the patent.

According to its abstract, the patent protects a chemotaxis assay procedure that is non-destructive of the cells being studied, which permits the performance of kinetic or time-dependent studies of cell migration from the same sample, and which produces objective measurements including the steps of: (a) labeling cells with a dye; (b) placing the labeled cells in a first chamber; (c) placing a chemical agent in a second chamber adjacent to said first chamber; (d) separating said first chamber from said second chamber with a radiation-opaque membrane that has a plurality of substantially perpendicular transverse pores therein; (e) stimulating the labeled cells on the side of the membrane closest to the second chamber with electromagnetic radiation of a first wavelength whereby the labeled cells will emit electromagnetic radiation of a second wavelength; and (f) measuring the emitted electromagnetic radiation from the side of the radiation-opaque membrane closest to the second chamber. The radiation-opaque membrane may comprise a dyed film or a film which has at least one radiation-blocking layer applied thereto, the abstract states.

Chempaq of Copenhagen, Denmark has been awarded US Patent No. 6,959,618, "Particle characterization apparatus."

Ulrik Larsen is the lone inventor listed on the patent.

According to its abstract, the patent protects an apparatus for characterizing cells in a biological liquid sample and operating according to the Coulter principle. The apparatus has a disposable sensor unit and a docking station for removably receiving the sensor unit. The sensor unit housing contains electrodes in each of two chambers separated by a wall containing an orifice. The housing is adapted to contain and retain disposal liquid pumped through the orifice during particle characterization operations, the abstract states.

Phylogency of Columbus, Ohio, has been awarded US Patent No. 6,960,430, "Screening methods for compounds useful in the regulation of cell proliferation."

Inventors listed on the patent are Vladimir Volloch and Michael Sherman.

According to its abstract, the patent protects drug-screening assays and methods for the treatment of proliferative disorders associated with elevated levels of heat shock protein 72 (Hsp72) expression in a cell. The invention is based on the discovery that overexpression of full-length Hsp72 protein, or the C-terminal protein binding domain of Hsp72, results in oncogenic transformation of cells, the abstract states.

The Scan

Interfering With Invasive Mussels

The Chicago Tribune reports that researchers are studying whether RNA interference- or CRISPR-based approaches can combat invasive freshwater mussels.

Participation Analysis

A new study finds that women tend to participate less at scientific meetings but that some changes can lead to increased involvement, the Guardian reports.

Right Whales' Decline

A research study plans to use genetic analysis to gain insight into population decline among North American right whales, according to CBC.

Science Papers Tie Rare Mutations to Short Stature, Immunodeficiency; Present Single-Cell Transcriptomics Map

In Science this week: pair of mutations in one gene uncovered in brothers with short stature and immunodeficiency, and more.