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Cellomics, DuPont, SurroMed, Honeywell Awarded Patents


Cellomics has received US Patent No. 6,716,588, “System for cell-based screening.” The patent covers automated systems, methods, screens, and software for the analysis of cell spreading. The invention involves providing cells containing fluorescent reporter molecules in an array of locations; contacting the cells with a test stimulus; acquiring images from the cells; and automatically calculating one or more morphological features that provide a measure of cell spreading.

EI du Pont de Nemours and Company has been issued US Patent No. 6,716,582, “Cellular arrays for the identification of altered gene expression.” The patent relates to the generation and use of a cellular array in combination with other genome-registered arrays for the determination of gene function and/or perturbation mode of action. Each cellular array consists of a number of microbial strains, and each strain comprises one reporter gene fusion made up of a gene or gene fragment operably linked to a reporter gene. Each gene or gene fragment has been “registered” or mapped to a specific location in the genome of the organism. The genome-registered collection may be used to determine alterations in gene expression under a variety of conditions, are amenable to rapid assay, and may be used to confirm, correct or augment data generated from DNA micro- array technology.

SurroMed has been awarded US Patent No. 6,687,395, “System for microvolume laser scanning cytometry.” The patent covers an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. It includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.

Honeywell International has received US Patent No. 6,700,130, “Optical detection system for flow cytometry.” The patent describes an optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from a central axis of a flow stream for providing light through different parts of the flow stream. One or more lenses are used to focus the light from the two or more light sources through the flow stream and onto a common focal point or region on the opposite side of the flow stream. One or more light detectors are then placed at, near, or around the common focal point or region. A processor or the like receives at least one output signal from the one or more light detectors to analyze and determine selected characteristics of the flow stream.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.