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Caliper, Surface Logix, Artecel, BioImage, and Aurora Win US Patents


Caliper Life Sciences has been awarded US Patent No. 7,001,716, "Continuous flow methods for monitoring time dependent reactions."

Inventors listed on the patent are Samuel Chan, Ring-Ling Chien, Andrea Chow, and Benjamin Wang.

According to its abstract, the patent protects methods for monitoring time-dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring of reaction kinetics over time, the abstract states. Examples of reactions that can be monitored with the described method include simple enzyme reactions, binding reactions between specific binding pairs (e.g., ligand-receptor binding); nucleic acid binding reactions; protein/nucleic acid binding reactions; protein-protein interactions, and the like; as well as complex cellular reactions (e.g., cellular activation or signaling cascade reactions); cellular viability reactions, or the like, the patent states.

Surface Logix has been awarded US Patent No. 7,001,740, "Methods of arraying biological materials using peelable and resealable devices."

Inventors listed on the patent are David Duffy, Gregory Kirk, Stewart Campbell, Olivier Schueller, and Melina Agosto.

According to its abstract, the patent protects devices and methods for performing assays on materials, particularly biological materials. The devices and methods make use of self-sealing members, which can be applied to a flat surface to form wells to facilitate immobilization of materials on the flat surface, then removed to yield a flat surface that facilitates the performance of processes on and/or detection of the immobilized material, the abstract states. According to the patent, the invention provides a novel multilevel array system that can be used in high-throughput screening, in the study of protein-protein interaction, cell-based assays, and other known biological assays.

Artecel Sciences has been awarded US Patent No. 7,001,746, "Methods and compositions for the differentiation of human preadipocytes into adipocytes."

Inventors listed on the patent are Yuan-Di Chang Halvorsen and William Wilkison.

According to its abstract, the patent protects methods and compositions for the consistent and quantitative differentiation of human preadipocytes isolated from adipose tissue into adipocytes bearing biochemical, genetic, and physiological characteristics similar to that observed in isolated primary adipocytes. Specific methods of the invention include incubating isolated human preadipocytes, plated at least about 25,000 cells/cm2, in a medium containing glucose; a cyclic AMP inducer such as isobutylmethylxanthine or forskolin; a glucocorticoid or glucocorticoid analogue; insulin or an insulin analogue; and a PPARγ agonist or a RXR agonist. The patent also describes media for the differentiation of human preadipocytes, human adipocytes differentiated by the methods of the invention, and transfected adipocytes. The patent also describes methods for determining the ability of a compound to affect the differentiation of human preadipocytes to adipocytes; for determining the ability of a compound to act as a PPARγ antagonist, and methods to identify novel polypeptides secreted from human adipocytes into the conditioned medium. The described methods and compositions have use in the drug discovery of compounds having relevance to the disease states of diabetes, obesity, and cardiovascular disease, and in the studies of these diseases, the abstract states.

BioImage has been awarded US Patent No. 7,001,986, "Fluorescent proteins."

Inventors listed on the patent include Sara Petersen Bjorn, Len Pagliaro, and Ole Thastrup.

According to its abstract, the patent protects a GFP with an F64L mutation and an E222G mutation. This GFP has a bigger Stokes shift compared to other GFPs, making it very suitable for high-throughput screening due to a better resolution. This GFP also has an excitation maximum between the yellow GFP variant and the cyan GFP variant, allowing for cleaner band separation when used together with those GFPs, the abstract states.

Aurora Discovery has been awarded US Patent No. 7,002,671, "Detector and screening device for ion channels."

Inventors listed on the patent are Roger Tsien, Peter Coassin, Andrew Pham, Alec Tate Harootunian, and Minh Vuong.

According to its abstract, the patent protects a detector assembly, fiber assembly, and screening system for optical measurements.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.