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Caliper Life Sciences, Caliper Discovery Alliances and Services, Genovis

Caliper Life Sciences this week announced that researchers using the LabChip EZ Reader platform for screening and profiling kinase inhibitors now have access to more than 200 kinase assays. The assays are available in Caliper's ProfilerPro reagent format, a pre-packaged, ready-to-use kit that enables in-house kinase profiling to be performed in a single day.

Caliper also announced this week the availability of two new service offerings from its Caliper Discovery Alliances and Services group — RapidKinase profiling and enzymatic Mechanism of Action studies.
The RapidKinase profiling service uses Caliper’s LabChip EZ Reader technology and ProfilerPro reagents to provide kinase profiling data to researchers within one week. The Mechanism of Action studies provide researchers with detailed information about the manner in which their compounds interact with enzymatic targets, and are important for characterizing allosteric inhibitors and assessing kinetic on and off rates.

Genovis launched NIMT FeOfection purple, the company announced this week. siRNA can now be transfected into suspension cell lines such as K562 and Jurkat cells, which are generally known as hard-to-transfect cells, the company said.

The transfection agent is based on a super paramagnetic core that is traceable in MRI and can be combined with other labeling entities for dual imaging purposes.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.