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Caliper, IMSB, Tecan

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Caliper Scores NOA For In Vivo Light Imaging Method 
 
Caliper Life Sciences last week announced it has received a Notice of Allowance from the US Patent and Trademark Office for a patent application covering key methods of in vivo, non-invasive imaging of light generated from within mammals.
 
The Notice of Allowance corresponds to U.S. patent application serial number 11/143,422 entitled, "Non-invasive localization of a light-emitting conjugate in a mammal." A U.S. patent corresponding to the Notice of Allowance will issue when the USPTO receives the requisite issuance fee.
 
According to the company, biophotonic imaging is expanding to include methods based on light sources that are conjugated with a biocompatible entity and administered to mammals. Caliper's newly allowed patent will cover many of these developments in biophotonic imaging science.
 
The new patent will cover the use of conjugates comprising any biocompatible entity and a light source, either fluorescent or bioluminescent. The biocompatible entity can be a cell, microorganism, particle, or biological molecule.
 

 
IMSB Scientists Use Tecan Workstations, RNAi to ID Viral Genes
 
Researchers at the Institute of Molecular Systems Biology in Zurich, Switzerland, this week announced they are using two customized Tecan Freedom EVO 200 liquid handling workstations as part of a study to identify the specific sets of host genes that viruses require to infect cells.
 
The investigators plan to individually silence 7,000 mammalian genes using RNAi, and measure how each silencing affects the abilities of 11 different viruses, including influenza, herpes, and SV40, to infect mammalian hosts.
 
One Freedom EVO workstation is equipped with a Te-MO 384-channel pipetting head to perform the transfection and infection assays. The second workstation has a Te-Stack stacker module and two fully integrated Cell-Works microscopes for automated quantification of the proportion of virus-transfected cells.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.