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Caliper, Bioarray Solutions, Zeiss Among Recent US Patent Winners

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Caliper Life Sciences has been awarded US Patent No. 6,958,221, "Cell flow apparatus and method for real-time measurements of patient cellular responses."

Inventors listed on the patent are Gregory Kaler and Pandi Veerapandian.

According to its abstract, the patent protects a method for determining the effect of each of a plurality of test agents on cells from a subject, and a method to profile patient cell responses to test agents.


Bioarray Solutions has been awarded US Patent No. 6,958,245, "Array cytometry."

Inventors listed on the patent are Michael Seul and Alice Li.

According to its abstract, the patent protects a method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements, the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon [and/or] oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. According to the patent's abstract, the invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The invention also enables sample preparation and handling for diagnostic assays and biochemical analyses in an array format, and the functional integration of these operations. In addition, the invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. Lastly, the patent also describes a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination.


Carl Zeiss has been awarded US Patent No. 6,958,811, "Method for the detection of dyes in fluorescence microscopy."

Inventors listed on the abstract are Ralf Wolleschensky and Gunter Moehler.

According to its abstract, the patent protects a method for optical detection of characteristic quantities of the wavelength-dependent behavior of an illuminated specimen, such as the emission behavior and/or absorption behavior. Preferably, the fluorescence and/or enzyme fluorescence comprises determining at least one spectral centroid and/or a maximum of the emission radiation and/or of the absorbed radiation. An arrangement for performing the method is described, the abstract states.

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