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Caliper and Science Applications International Awarded Recent Patents

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Caliper Life Sciences has been awarded US Patent No. 6,801,875, “Methods, systems, and software for performing measurements.”

Inventors listed on the patent are Jeffrey Wolk, Irina Kazakova, and Morten Jensen.

The patent protects methods of measuring widths of illumination spots and distances between two points, and predicting detected signal widths. According to the patent, the invention has applications in cell-based screening and separation assays because many of these assays generate detectable signals by passing fluorescently labeled cells through laser induced illumination spots incident within device cavities. According to the inventors, “an improperly focused illumination spot having a width smaller than the cavity width at the point of incidence typically yields biased results, such as incorrect ratios of the number of labeled to unlabelled cells. Furthermore, knowledge of accurate illumination spot sizes allows the velocity of cells flowing through the cavity to be more easily calculated.”


Science Applications International Corporation has been awarded US Patent No. 6,800,452, “Automated methods for simultaneously performing a plurality of signal-based assays.”

Inventors listed on the patent are John McNeil, Michael Akong, Donald Mierzeski, Gonul Velicelebi, and David Karlton.

The patent covers an automated detection system that includes a robotic fluid handling system for performing a plurality of assays; a detection system for imaging the assays as they are performed; and a computer control, data acquisition, and data analysis system for controlling the operation of the fluid-handling and detection system and for collecting and analyzing imaging data. A method for performing simultaneous assays is also provided that includes the steps of simultaneously distributing a predetermined amount of a liquid solution to each of a plurality of samples, simultaneously exposing the wells to excitation radiation, simultaneously detecting signals emitted from the wells using a detector comprising a single imaging means, and simultaneously controlling and coordinating the distribution, excitation, and detection using a computerized controller.

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