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Caliper and Cellomics Among Recent Winners of US Patents


Caliper Life Sciences has been awarded US Patent No. 6,986,837, "Microfluidic controller and detector system with self-calibration."

Inventors listed on the patent are Calvin Chow, Morten Jensen, Colin Kennedy, Michael Lacy, and Robert Nagle.

According to its abstract, the patent protects a microfluidic controller and detector system and method for performing screening assays. The microfluidic controller and detector system comprises a fluidic chip that includes at least two intersecting channels and a detection zone; a fluid direction system comprising an electrical interface configured for electrical contact with the at least two intersecting channels; an optics block having an objective lens disposed adjacent to the detection zone; and a control system coupled to the optics block and adapted to receive and analyze data from the optics block. The electrical interface generally includes electrodes configured for electrical contact with the intersecting channels and coupled to electrode channels for supplying electrical input to the electrodes. A reference channel is optionally provided to calibrate the electrode channels, the abstract states.

Cellomics has been awarded US Patent No. 6,986,993, "System for cell-based screening."

Inventors listed on the patent are Richik Ghosh, Robbin DeBiasio, and Prem Janardhan.

According to its abstract, the patent protects systems, methods, screens, reagents, and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for those that specifically affect neurite outgrowth.

Gordon Hudson has been awarded US Patent No. 6,987,563, "Luminescense validation microplate."

Hudson was previously or is currently an employee of BMG Labtech.

According to its abstract, the patent protects a luminescence validation microplate for testing the validity of a luminescence microplate reader. The microplate can efficiently and cost-effectively test luminescence microplate readers with a series of tests to determine linearity, alignment, reproducibility, and cross talk all on the same plate with improved results, the abstract states.

The Scan

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.

Team Presents Cattle Genotype-Tissue Expression Atlas

Using RNA sequences representing thousands of cattle samples, researchers looked at relationships between cattle genotype and tissue expression in Nature Genetics.

Researchers Map Recombination in Khoe-San Population

With whole-genome sequences for dozens of individuals from the Nama population, researchers saw in Genome Biology fine-scale recombination patterns that clustered outside of other populations.

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.