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Caliper, AGY Thera, Myriad, Beckman Coulter Among Patent Winners


Caliper Life Sciences was awarded US Patent No. 6,841,193, “Surface coating for microfluidic devices that incorporate a biopolymer-resistant moiety.”

Inventors listed on the patent are Hua Yang and Steven Sundberg.

According to its abstract, the patent protects methods of coating the surfaces of the microchannels of a microfluidic device. These methods include silyating a first portion of the surfaces of the microchannels with a reagent to produce a first-silyated surface; then silyating a second portion of the surfaces with a second reagent to produce a second-silyated surface.

According to the patent, the flexibility of devices and systems incorporating such a surface should permit the integration of additional operations, such as structures, reagents, and systems for performing operations both upstream and downstream. Such upstream operations include sample handling and preparation operations, e.g., cell separation, extraction, purification, amplification, cellular activation, labeling reactions, dilution, aliquoting, and the like; while downstream operations may include similar operations, including, e.g., separation of sample components, labeling of components, assays, and detection operations, the patent states.

AGY Therapeutics has been awarded US Patent No. 6,841,351, “High-throughput transcriptome and functional validation analysis.”

Inventors listed on the patent are Li Gan, Mirella Gonzalez-Zulueta, Kristin Anton, Richa Wilson, Thorsten Melcher, and Daniel Chin.

According to its abstract, the patent protects methods for correlating genes and gene function. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity, and then validating the role of the candidate gene in establishment of such a cellular state or activity. Certain methods utilized RNA interference techniques in the validation process, the abstract states.

Myriad Genetics has been awarded US Patent No. 6,841,352, “Mating-based method for detecting protein-protein interaction.”

Kirill Ostanin is the inventor listed on the patent.

According to its abstract, the patent protects a mating-based yeast two-hybrid system for determining whether a test polypeptide interacts with another test polypeptide in the presence or absence of one or more test compounds. The system is useful in detecting protein-protein interactions and in identifying compounds capable of modulating protein-protein interactions.

Philadelphia Health & Education has been awarded US Patent No. 6,841,354, “Screening assay for anti-thrombotic/anti-platelet activity.”

Gerald Soslau is the inventor listed on the patent.

According to its abstract, the patent protects a method for screening for anti-thrombotic/anti-platelet agents, where the method is based on inhibition of the GP Ib, PAR-1, and/or PAR-4 pathways by the potential anti-thrombotic/anti-platelet agent.

Beckman Coulter has been awarded US Patent No. 6,841,379, “Conductive microplate.”

Robert Matson is the inventor listed on the patent.

According to its abstract, the patent protects a conductive microplate device for the detection of target biomolecules in a sample. The microplate comprises an assembly of a porous substrate and a conductive layer, wherein the assembly is sealed into the bottom of at least some wells of the microplate, the abstract states. The porous substrate has a top surface and a bottom surface, the top surface comprising a plurality of covalently attached probe biomolecules. The covalently attached probe biomolecules are reactive with the target biomolecules contained in the sample. The conductive layer, which is attached to the bottom surface of the porous substrate, is adapted to receive voltage. Microplates of the present invention can be easily adapted for use with robotic workstations, the abstract states.


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