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BTX, PerkinElmer, Oz Biosciences

BTX this week introduced MicroPoration, a new method for non viral transfections. With this new method, transfection takes place in the actual pipette tip. According to the manufacturer, this technique provides efficient electroporation of hard-to-transfect cells.
The system consists of a high-performance pulse generator, safety chamber, and MicroPorator pipette.
The high-performance pulse generator has a graphical user interface to facilitate setting up and operating the machine. All electrical parameters including voltage, number of pulses, and pulse duration are controlled by the user. Pre-optimized electrical parameters are provided and updated through the BTX technical support group. 

PerkinElmer last week announced that it has expanded its portfolio of HTS LANCE assays with the release of LANCE Ultra. The assay is designed with a particular focus on applications for kinase targets.
LANCE Ultra utilizes ULight, a low molecular weight, red-shifted fluorescent dye that enhances the performance of time resolved fluorescence resonance energy transfer assays by increasing the range of identifiable targets. The assay is designed with a particular focus on applications for kinase targets.

PerkinElmerlast week also announced the launch of two new luminescent gene reporter assays kits, steadylite plus and britelite plus.
According to the company, steadylite plus and britelite plus are highly sensitive firefly luciferase reporter gene assay kits for the quantification of gene expression in cells. Steadylite plus is designed for batch-processing systems and britelite plus is designed for continuous process systems.
Both steadylite plus and britelite plus kits are suitable for high-density microplates such as 384- and 1536-well plates in HTS environments. Steadylite plus can also be used for smaller-scale sample analysis in 96-well plates when higher sensitivity is required.  

PerkinElmer last week also announced the launch of its 1536 Head LumiLux Cellular Screening Platform for HTS and uHTS kinetic flash and glow luminescent cellular assays.  

The manufacturer said that the platform is the only dedicated flash luminescence instrument that enables simultaneous 1536 “inject and read” flash luminescence assays.

The platform also has a cell stirrer feature that allows it to work with suspension cells for uHTS screens. The 1536 LumiLux head accessory is fully field-upgradeable, or available as part of a complete screening system.  

Oz Biosciences this week launched Pro-DeliverIN, a reagent that enables the intracellular delivery of biologically active proteins. According to the company, this lipid-based formulation is the first serum-compatible reagent to deliver functional proteins into living cells.
Pro-DeliverIN is able to capture proteins through electrostatic and hydrophobic interactions. Consequently, chemical or genetic covalent linking is not necessary, the company said.
Pro-DeliverIN facilitates the study of specific protein functions, protein localization, and the elucidation of new molecular mechanisms.

Oz Biosciences this week also launched Ab-DeliverIN, which it says is the first dedicated intracellular antibody delivery reagent. Ab-DeliverIN forms non-covalent complexes with antibodies through electrostatic and hydrophobic interactions. Consequently, chemical or genetic binding is unnecessary. 

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.