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BresGen Awarded US Patent

BresGen has been awarded US Patent 7,432,104, “Methods for the culture of human embryonic stem cells on human feeder cells.”
The inventors listed on the patent are Maisam Mitalipova and Ian Lyons.
According to its abstract, the patent describes methods and cell culture medium for the generation of human pluripotent embryonic stem cells. Human embryonic stem cells are cultured with human granulosa feeder cells, muscle cells, fallopian ductal epithelial cells, bone marrow stromal cells, and skin fibroblasts, and the embryonic stem cells maintain their pluripotent phenotype. The human pluripotent embryonic stem cells can be cultured without feeder cells, and in the presence of supplemental growth factors. They can alternatively be cultured with conditioned medium obtained from a cell culture capable of maintaining human embryonic stem cells in a pluripotent state.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.