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Bioseek, Molecular Devices, the Regents of University of California, the Norwegian Food Research Institute, and the University of Washington Awarded US Patents

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Bioseek has been awarded US Patent 7,266,458, “BioMAP analysis.”
 
The inventors listed on the patent are Ivan Plavec, Ellen Berg, and Eugene Butcher.
 
According to the patent abstract, the involvement of an expression product in a cell in a pathway is determined by genetically modifying the cell, incubating the cell with predetermined factors in an induced physiological state, and measuring parameters affected by the pathway. Changes in the levels of the parameters as a result of the presence of the expressed product indicate that the expression product is involved with the pathway, that abstract stated.
 

 
Molecular Devices has been awarded US Patent 7,265,829, “Reflective optic system for imaging microplate readers.”
 
The inventors listed on the patent are Wu Jiang, Todd French, and David Stumbo.
 
The patent describes a reflective light imaging system for use in the high-throughput screening of samples disposed in multiple-well plates. The abstract said that the system can include a set of mirrors and lenses. As described in the abstract, the first mirror has a central aperture through which light from the object passes. The first mirror also has a concave reflective surface that faces the image plane. The second mirror has a convex reflective surface. The system can include an aberration correction system positioned between the second mirror and the image plane, and an optical sensor near the image plane, the abstract said. Light from an object passes through the central aperture of the first mirror and is reflected off the convex surface of the second mirror. The light then strikes the reflective surface of the first mirror. The light from the first mirror is then collected by the aberration correction system and transmitted toward the image plane.
 

 
The Regents of University of California have been awarded US Patent 7,262,269, “Method for screening combinational bead library; ligands for cancer cells.”
 
The inventors listed on the patent are Kit Lam and Derick Lau.
 
According to the abstract, the invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of epithelial and non-epithelial cells. Cells are incubated with a compound bead library for 24 to 72 hours, allowing them to attach and grow on the beads, the abstract said. Those beads with cells growing are removed, and the ligand on the bead is identified. The patent also provides ligands specific for cancer cells.
 

 
The Norwegian Food Research Institute in Matforsk has been awarded US Patent 7,262,009, “Method of cell detection.” 
 
The inventor listed on the patent is Knut Rudi.
 
The patent describes a method of distinguishing between living and dead cells in a sample. The method includes: (a) contacting the sample with a viability probe [that] modifies the nucleic acid of dead cells within the sample; and (b) detecting nucleic acid from the cells in the sample, wherein detection involves binding of one or more oligonucleotide probes to a target sequence within the nucleic acid. The patent also covers a method of detecting cells in a sample, which includes: (a) contacting the sample with a viability probe that labels the nucleic acid of dead cells within the sample; (b) separating the nucleic acid from the cells into labeled and non-labeled fraction; and (c) detecting the nucleic acid in one or both of the fractions.
 

 
The University of Washington has been awarded US Patent 7,258,837, “Microfluidic device and surface decoration process for solid phase affinity binding assays.”
 
The inventors listed on the patent are Paul Yager and Elena Garcia.
 
This patent provides a microfluidic device for use in the detection of one or more analytes in a fluid using solid-phase affinity binding assays, according to its abstract. The device offers a practical, easy-to-use, portable, inexpensive, robust analytical system for the parallel and quantitative detection of multiple analytes. In addition, this invention provides methods and devices for the formation of concentration gradients of capture molecules immobilized on a solid phase, the abstract said.

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