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Becton, Dickinson, Millipore, and the University of South Carolina Awarded US Patents

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Becton, Dickinson has been awarded US Patent 7,338,778, “Luminescent method for determining cell oxygen consumption.”
 
The inventors listed on the patent are J. Bruce Pitner, John Hemperly, Richard Guarino, Magdalena Wodnicka, David Stitt, Gregory Burrell, Timothy Foley, and Patrick Beaty.
 
The patent provides methods for the detection and evaluation of metabolic activity of eukaryotic and/or prokaryotic cells based upon their ability to consume dissolved oxygen, its abstract stated. The methods use a luminescence detection system, which makes use of the sensitivity of the luminescent emission of certain compounds to the presence of oxygen, which quenches the compound's luminescent emission in a concentration-dependent manner. The respiration of eukaryotic and/or prokaryotic cells will affect the oxygen concentration of a liquid medium in which they are immersed.
 

 
Millipore has been awarded US Patent 7,338,773, “Multiplexed assays of cell migration.”
 
The inventors listed on the patent are Simon Goldbard, Ilya Ravkin, and Oren Beske.
 
According to its abstract, the patent describes systems, including methods, apparatus, compositions, and kits, for a multiplexed assay of cell migration with subdivided cell holders and/or microplates.
 

 
The University of South Carolina has been awarded US Patent 7,338,517, “Tissue scaffold having aligned fibrils and artificial tissue comprising the same.”
 
The inventors listed on the patent are Michael Yost, C. Michael Gore, Louis Terracio, Richard Goodwin, and Edie Goldsmith.
 
Its abstract said the patent describes a tubular tissue scaffold that comprises a tube having a wall, wherein the wall includes biopolymer fibrils that are aligned in a helical pattern around the longitudinal axis of the tube, and the pitch of this helical pattern changes with the radial position in the tube wall. The scaffold is capable of directing the morphological pattern of attached and growing cells to form a helical pattern around the tube walls, according to the abstract.
 
The inventors also disclosed an apparatus for producing such a tubular tissue scaffold. The apparatus comprises a biopolymer gel dispersion feed pump that is operably connected to a tube-forming device having an exit port. The tube-forming device is capable of producing both a tube from the gel dispersion while providing an angular shear force across the wall of the tube, and a liquid bath positioned to receive the tubular tissue scaffold from the tube-forming device. A method for producing the tubular tissue scaffolds is also provided. Methods for using the artificial tissue comprising living cells attached to a tubular tissue scaffold are also described.

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