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Beckman Coulter, Applied Precision, SVision, Invitrogen

Beckman Coulter this week introduced the multi-platform loader, or MPL, option for its Cell Lab Quanta SC bench-top flow cytometer.
According to Beckman, the MPL enables handling of a variety of plate types including 96- and 384-well plates, chilled plates, or a 24 ViCell sample cup holder. Beckman said it has also enhanced the Quanta SC software to enable easy setup and programming of the MPL. Furthermore, the company said, the MPL acts as a pipetting station, aspirating from eight sample cups on a reagent tray. Ideal applications for the MPL option include high-throughput cell-based assays and cell viability analyses in drug discovery, Beckman said.

Applied Precision this week launched two new imaging systems in its DeltaVision restoration imaging line of products: the PersonalDV and DeltaVision Core.
The PersonalDV is a smaller, more economical version of its predecessor, DeltaVision RT, and is designed for individual academic research labs and biotech startups, Applied Precision said.
DeltaVision Core is designed to address higher-end market needs for imaging cell kinetics, Applied Precision said. This system enables increased probes, multiple fields of view, expanded and faster data acquisition, and increased storage and computing capacity for high-resolution, multiplexed live-cell imaging. The DeltaVision Core is equipped to handle extensive time course experiments of more than 1,000 hours of continuous imaging.

SVision said this week that it has commenced enrollment of an early adopter program for its SVCell-Live image-analysis software.
The new live-cell module extends the capability of the core SVCell software to address time-lapse microscopy applications. SVCell-Live automatically detects and tracks cells or subcellular objects in time-lapse images, the company said. It can define an accurate boundary for the object over time for kinetic shape analysis, and can model kinetic gain or loss of fluorescence. The software can be used to characterize dynamic events and phenotypes in time-lapse, multi-channel fluorescence, phase contrast, or brightfield images.
The early adopted program began on Dec. 10 and will run through May 31, 2007, the company said. Interested parties can find more information on the program on the company’s website.

Invitrogen has introduced iGene, an online scientific resource that allows researchers to search for experimental reagents by gene or protein.
The iGene platform joins Invitrogen’s iProtocol library and iPath bioatlas in the company’s suite of online resources. The platform integrates all known human, mouse, and rat genes and proteins into one database, and allows scientists to filter through more than 250,000 products related to their gene or protein of interest, Invitrogen said. Researchers can search using several criteria such as keyword, gene accession number, gene symbol, or batch search, and search results link to external resources at the National Center for Biotechnology Information and Invitrogen’s iPath, the company said.
Invitrogen also announced the launch of its Premo cameleon calcium sensor for imaging applications and high-throughput compound screening.
Premo is a genetically encoded fluorescent protein-based sensor for cellular calcium signal measurements. It provides a ratiometric readout at visual excitation wavelengths in the presence of calcium, and interferes minimally with cellular physiology, Invitrogen said. Pre-packaged in BacMan insect virus delivery format, the sensor is applicable to a broad range of mammalian cells, including neuronal, primary, and stem cells.

The Scan

Genetic Tests Lead to Potential Prognostic Variants in Dutch Children With Dilated Cardiomyopathy

Researchers in Circulation: Genomic and Precision Medicine found that the presence of pathogenic or likely pathogenic variants was linked to increased risk of death and poorer outcomes in children with pediatric dilated cardiomyopathy.

Fragile X Syndrome Mutations Found With Comprehensive Testing Method

Researchers in Clinical Chemistry found fragile X syndrome expansions and other FMR1 mutations with ties to the intellectual disability condition using a long-range PCR and long-read sequencing approach.

Team Presents Strategy for Speedy Species Detection in Metagenomic Sequence Data

A computational approach presented in PLOS Computational Biology produced fewer false-positive species identifications in simulated and authentic metagenomic sequences.

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.