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Beckman Coulter, Applied Biosystems, Cellexus Biosystems

Beckman Coulter this week introduced the IOtest Anti-p75/AIRM1-PE conjugated antibody, featuring an exclusive clone, Z176.
Beckman said that p75/AIRM1, whose ligand is not yet known, is an inhibitory molecule expressed by natural killer and myelomonocytic cells. Engagement of p75/AIRM1 with a purified monoclonal antibody has been shown in recent scientific papers to inhibit the proliferation of myeloid cells, and thus p75/AIRM1 may represent a useful marker for studying the normal myeloid differentiation process, Beckman said.

Applied Biosystems this week announced a series of new reagents for chemokine research.
Each non-radioactive chemokine is labeled with FMAT Blue and optimized for performance with ABI’s 8200 Cellular Detection System, the company said. FMAT Blue-labeled chemokines have an excitation maximum of 638 nm and an emission maximum of 660 nm.

Cellexus Biosystems this week announced the publication of a new technical note for the amplification of CHO cells in the company’s CellMaker Lite instrument.
The technical note reports the findings of an undisclosed pharmaceutical company that used the CellMaker LIte to produce eight liters of CHO cells to a higher concentration and viability cell count than was achieved in a shaker flask with a culture volume of 100 mL and agitated at 160 rpm in a CO2 incubator, Cellexus said in a statement.
Cellexus said that the CellMaker Lite, unlike other bioreactors, does not need to be shaken, stirred, rocked, or rolled to produce cells.
The technical note is available on the company’s website.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.