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Aviva Biosciences, UCal, Cadus Tech, GE Healthcare Among Recent US Patent Winners

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Aviva Biosciences has been awarded US Patent No. 7,081,192, “Methods for manipulating moieties in microfluidic systems.”
 
Inventors listed on the patent are Xiaobo Wang, Lei Wu, Jing Cheng, Weiping Yang, and Junquan Xu.
 
According to its abstract, the patent protects a method for manipulating a moiety in a microfluidic application. The method comprises coupling a moiety (such as a cell, a cellular organelle, a virus, a molecule, or aggregate or complex thereof) to be manipulated onto the surface of a binding partner of said moiety to form a moiety-binding partner complex; and manipulating said complex with a physical force in a chip format. The manipulation is effected through a combination of a structure that is external to the chip and a structure that is built into the chip, the abstract states.
 

 
The University of California has been awarded US Patent No. 7,081,227, “Amphiphilic mediated sample preparation for micro-flow cytometry.”
 
Inventors listed on the patent are David Clague, Elizabeth Wheeler, and Abraham Lee.
 
According to its abstract, the patent protects a flow cytometer that includes a flow cell for detecting the sample, an oil phase in the flow cell, a water phase in the flow cell, an oil-water interface between the phases, a detector for detecting the sample at the oil-water interface, and a hydrophobic unit operatively connected to the sample. The sample and the hydrophobic unit are placed in an oil and water combination, and the sample is detected at the interface between the phases.
 

 
The University of California has also been awarded US Patent No. 7,081,343, “Methods for identifying modulators of NF-κB activity.”
 
Inventors listed on the patent are Lin-feng Chen, Wolfgang Fischle, Eric Verdin, and Warner Greene.
 
According to its abstract, the patent protects methods for identifying agents that modulate NF-κB activity through modulation of the acetylation and deacetylation of the RelA subunit of NF-κB.
 

 
Cadus Technologies has been awarded US Patent No. 7,081,360, “Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties.”
 
Inventors listed on the patent are Anupama Nadkarni and Joshua Trueheart.
 
According to its abstract, the patent protects modified forms of G protein-coupled receptors which display altered ligand binding and/or coupling properties, as well as cells expressing such receptors and assays utilizing these cells for screening and identifying compounds that specifically modulate the activity of these modified GPCRs. Yeast or mammalian cells can be used to express such receptors, the abstract states. The subject assays enable rapid screening of large numbers of compounds to identify those which are receptor agonists or antagonists. The patent also protects compositions of matter, such as these novel receptors, novel recombinant yeast cells, and novel gene constructs. The instant assays provide a convenient format for discovering compounds that can be useful in modulating cellular function, as well as in understanding the pharmacology of compounds that specifically interact with these modified GPCRs, the abstract states.
 

 
GE Healthcare has been awarded US Patent No. 7,081,365, “Scintillation proximity test.”
 
Robert Jessop is the sole inventor listed on the patent.
 
According to its abstract, the patent protects scintillation proximity assays performed in multiwell plates where a charge coupled device is used to image the wells. Conventional phosphors emit blue light (350-450 nm) which is absorbed by yellow or brown assay components. This problem is addressed by the use of phosphors that emit radiation of longer wavelength (480-900 nm), the abstract states.

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