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Automated Cell, Geron, Genoptix, Kairos, Cytoscan Win US Patents


Automated Cell has been awarded US Patent No. 6,830,931, “Method and apparatus for monitoring of proteins and cells.”

Inventors listed on the patent are Alfred Bahnson, Douglas Koebler, Charalambos Arthanassiou, Raymond Houck, Kris Sachsenmeier, and Lei Qian.

According to its abstract, the patent protects an apparatus for monitoring proteins and cells. The apparatus includes a plate with wells in which cells are disposed, and includes means for analyzing the effect of proteins and other biological and chemical moieties on the cells, the abstract states. The patent also protects an apparatus for aligning light in a well of a plate for holding cells; a method for lighting a well; a method for determining a condition of a cell; an apparatus for indicating a condition of a cell; a method for establishing a focus profile of a plate having wells for holding cells; and a method and apparatus for manipulating cells, the abstract states.

Geron Corporation has been awarded US Patent No, 6,833,268, “Making neural cells for human therapy or drug screening from human embryonic stem cells.”

Melissa Carpenter is the inventor listed on the patent.

According to its abstract, the patent protects populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations, such as embryonic stem cells, in a cocktail of growth conditions that initiates differentiation and establishes the neural progenitor population, the abstract states. The progenitors can be further differentiated in culture into a variety of different neural phenotypes, including dopaminergic neurons. The differentiated cell populations or the neural progenitors can be generated in large quantities for use in drug screening and the treatment of neurological disorders, the abstract states.

Genoptix has been awarded US Patent No. 6,833,542, “Method for sorting particles.”

Inventors listed on the patent are Mark Wang, Eugene Tu, James O’ Connell, Kristie Lykstad, and William Butler.

According to its abstract, the patent describes a method for sorting a particle of interest from a plurality of particles, and includes the steps of determining an absorption maxima of the particle of interest; providing a light source for generating a beam of coherent light at a wavelength correlating to the absorption maxima; providing a plurality of particles on a support surface; and imparting relative motion between the beam of coherent light and the plurality of particles so as to cause differential movement between the particle of interest and the plurality of particles. The particle of interest is then collected, the abstract states.

Kairos Scientific has been awarded US Patent No. 6,834,122, “Visualization and processing of multidimensional data using prefiltering and sorting criteria.”

Inventors listed on the patent are Mary Yang, Edward Bylina, William Coleman, Michael Dilworth, Steven Robles, and Douglas Youvan.

According to its abstract, the patent protects a method for organizing and analyzing complex multidimensional datasets generated by digital imaging spectroscopy by applying software and computer-based methods comprising sorting algorithms. Combinations of these algorithms to images and graphical data allow pixels or features to be rapidly and efficiently classified into meaningful groups according to defined criteria, and multiple rounds of pixel or feature selection may be performed based on independent sorting criteria, the abstract states. In one embodiment, sorting by spectral criteria (e.g., intensity at a given wavelength) is combined with sorting by temporal criteria (e.g., absorbance at a given time) to identify microcolonies of recombinant organisms harboring mutated genes encoding enzymes having desirable kinetic attributes and substrate specificity. User-defined criteria can be incorporated into the sorting process by means of a graphical user interface that comprises a visualization tools including a contour plot; a sorting bar and a grouping bar; an image window; and a plot window that allow run-time interactive identification of pixels or features meeting one or more criteria, and display of their associated spectral or kinetic data. These methods are useful for extracting information from imaging data in applications ranging from biology and medicine to remote sensing, the abstract states.

Cytoscan Sciences has been awarded US Patent No. 6,834,238, “Method for identifying optical contrast enhancing agents.”

Daryl Hochman is the inventor listed on the patent.

According to its abstract, the patent provides optical detection techniques for the assessment of the physiological state, health, and/or viability of biological materials, including cells, tissues, organs, and subcellular components. The inventive techniques may be employed in high throughput screening of potential diagnostic and/or therapeutic agents, the abstract states.


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