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Arryx, Znomics, Promega

Arryx has added the HOTkit Complete holo-tweezers solution to its proprietary Holographic Optical Trapping (or HOT) product line, the company announced this week. 
In cell arraying, multiple cells are patterned on a coverslip for cell signaling experiments with holo-tweezers. In targeted transfection, holo-tweezers are used to simultaneously photoporate cells and create locally high concentrations of DNA, increasing the efficiency of expression in the specifically chosen cells.
HOT technology is based on a technique known as optical trapping, which works by using light to create microscopic "tweezers" that can manipulate particles in the microscopic field of view. The manufacturer explained that what makes its holo-tweezers unique is that instead of being limited to a stationary or single beam, the power of holography allows the user to create hundreds of traps to grab and move multiple cells and particles in three dimensions with point-and-click mouse control.
The LabRyx software on the HOT workstation automates the creation of traps and controlling the microscope for applications such as morphology-based flow sorting and particle recognition and isolation.
According to the company, the HOTkit Complete holo-tweezers solution integrates all of the core components necessary for a biologically optimized tweezing system — the Spatial Light Modulator, Collimated Fiber Laser, CCD Camera, and HOT Workstation with LabRyx software — into a complete package that can be incorporated into virtually any research grade microscope or imaging modality.

Znomics this week launched its Human Disease Library, which includes mutations in 193 key genes, representing nearly 50 percent of the known druggable disease genes.
David Ransom, director of genetics and functional genomics at Znomics, said in a statement that the library, which is a subset of the ZeneMark library of zebrafish strains, will ultimately “contain mutations in the majority of known human disease genes. These strains can be used to model complex human diseases in the zebrafish.”

Promega has released the GloMax multi-detection system, the company announced this week.
Now with multi-mode capability, GloMax also reads fluorescence and absorbance detection in 96-well plates. This is particularly applicable for cancer research, cell biology, and drug screening, the manufacturer said.
GloMax has a touch-screen interface and operates as an independent workstation. A computer in not necessary to operate the instrument. Scientists can run experiments on their schedule and then transfer data to a computer at any time via a USB port.  

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.