Applied Biosystems has been awarded United States Patent 7,428,047, “Time-delay integration in a flow cytometry system.”
Mark Oldham, Eric Nordman, Richard Reel, and John Shigeura.
The patent provides an apparatus for detecting analytes in a sample. According to the abstract, the apparatus can include: a flow cytometry system comprising one or more detection zones; one or more irradiation sources disposed for irradiating the detection zones; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the detector(s) for effecting time-delay integration of the charges by accumulating the charges before reading them at the output of the detector(s); and a sorting mechanism, for example, to effect flow cytometry. The patent also describes methods for detecting analytes in a sample.