Anticancer of San Diego has been awarded US Patent 6,905,831, "Real time measurement of cellular responses."
Inventors listed on the patent are Ping Jiang, Mingxu Xu, and Meng Yang.
The patent protects a method for stably modifying living cells so that they emit different colors from the cytoplasm and nucleus, "thus permitting analysis of the status of said cells and the effect of agents on said cells either by visual or instrumentally aided observation," the patent abstract states. In addition, rates of proliferation and drug sensitivities can be determined in vitro in real time by the use of cells modified to express a single fluorescent protein and observing fluorescence intensity as a function of time, the abstract states.
Abbot Laboratories has received US Patent 6,905,823, "Cellular arrays and methods of detecting and using genetic disorder markers."
Inventors listed on the patent are Olli-P Kallioniemi, Uwe Richard M ller, Guido Sauter, Juha Kononen, and Maarit Barlund.
This patent covers a method for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array, and performing a different biological analysis of each copy, the abstract states. The results of the different biological analyses are compared to determine if there are correlations between the results of the different biological analyses at each assigned location. In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular analyses. Other examples of suitable tissues that can be placed in the matrix include tissue from transgenic or model organisms, or cellular suspensions (such as cytological preparations or specimens of liquid malignancies or cell lines).