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AnaSpec, Thermo Fisher Scientific, Carestream Molecular Imaging, CyBio

AnaSpec this week introduced a series of luminescent and non-luminescent calcium indicators. The aequorin complex comprises a 22 KD apoaequorin protein, molecular oxygen, and the luminophore coelenterazine.
AnaSpec offers coelenterazine and several synthetic coelenterazine analogs for reconstituting aequorin in cells that have been transfected with apoaequorin cDNA. In addition to native coelenterazine, the company also offers several derivatives of coelenterazine that confer different Ca2+ affinities and spectral properties on the aequorin complex.
Along with fluorescent and luminescent Ca2+ detection reagents, AnaSpec also offers several non-luminescent compounds for measuring and manipulating intracellular and extracellular Ca2+. Among these, 5,5’-dimethyl BAPTA is the most powerful Ca2+ chelator, the company said, and is also available in cell-permeable AM ester form.   

Thermo Fisher Scientific this week introduced validation services for Thermo Scientific laboratory equipment. The program provides validation services for products including, but not limited to, ultra-low-temperature freezers, refrigerators, incubators/environmental chambers, centrifuges, and biological safety cabinets.
This program offers a portfolio of factory-developed protocols, field validation, and annual requalification services for users with laboratory equipment in GxP environments. 
The Thermo Scientific validation program allows simultaneous equipment purchase and installation, operation, and performance qualification. The program allows customers to review protocols and schedule validation before their equipment arrives.
Included in the validation package are all protocols, supporting documents, critical pass/fail analysis, and certificates of training required for compliance in GxP environments. 

Carestream Molecular Imaging this week announced that it has released two new gel imaging systems to advance its line of Kodak Gel Logic systems for in vitro applications in life science research laboratories.
The company said that the Kodak Gel Logic 112 and Kodak Gel Logic 212 imaging systems deliver improved image quality and data acquisition for documenting and analyzing electrophoresis gels, colormetric blots, plates, and more.
The Kodak Gel Logic 112 system is a modular gel imaging system that delivers superb image quality and analysis performance
The Kodak Gel Logic 212 system is designed for medium-to-large labs where workflow, high-sample throughput, safety, and high-quality image analysis is critical. The 212 system can also be upgraded to the Kodak Gel Logic 1500 and 2200 imaging Systems — advanced systems for imaging a wide array of samples including chemiluminescence, fluorescence, and chromogenic gels, blots, and plates.
Both systems are equipped with a 1.4 million-pixel CCD camera that can accumulate up to 14 bits of data. Additionally, software support has been added for the Macintosh OSX (version 10.5), Windows XP, and Windows Vista Professional operating systems. 
All Kodak Gel Logic systems ship with Kodak Molecular Imaging Software.

CyBio this week announced the launch of its CyBi-Drop dispenser, which the company said has been specifically developed to protect cells during dispensing.
Integrated cell circulation holds the cells in suspension before dispensing to avoid cell sedimentation effects. Through the combination of cell circulation and patented cell dispensing technology, the cells will be distributed evenly and without mechanical stress into the microplate, the company said.
The dispensing combs of the CyBi-Drop allow for precision and accuracy when dispensing a wide range of liquids, the manufacturer said. Depending on the application, they can be exchanged by the users themselves.
Investigators can use software for automated volume adjustment and the individual setting of dispensing parameters. This allows the dispensing of reagents onto an adherent cell monolayer without disrupting it during the dispensing.
For more complex applications, the CyBi-Drop can be combined as a compact platform with multi-channel pipettors of the CyBi-Well product line, as well as with the new CyBi-WellFlex.

The Scan

Myotonic Dystrophy Repeat Detected in Family Genome Sequencing Analysis

While sequencing individuals from a multi-generation family, researchers identified a myotonic dystrophy type 2-related short tandem repeat in the European Journal of Human Genetics.

TB Resistance Insights Gleaned From Genome Sequence, Antimicrobial Response Assays

Researchers in PLOS Biology explore M. tuberculosis resistance with a combination of sequencing and assays looking at the minimum inhibitory concentrations of 13 drugs.

Mendelian Disease Genes Prioritized Using Tissue-Specific Expression Clues

Mendelian gene candidates could be flagged for further functional analyses based on tissue-specific transcriptome and proteome profiles, a new Journal of Human Genetics paper says.

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.