Allergan has been awarded US Patent No. 6,991,910, "High-throughput screen for identifying channel blockers that selectively distinguish transient from persistent sodium channels."
Inventors listed on the patent are Joseph Adorante, George Ehring, and John Donello.
According to its abstract, the patent protects a method for identifying a Na+ channel blocker, including providing a cell containing a Na+ channel, demonstrating both a transient and a persistent current. The cell includes a potassium (K+) channel and a Na/K ATPase (Na+ pump). A fluorescent dye is disposed into the well. The fluorescent dye is sensitive to change in cell membrane potential in order to enable optical measurement of cell membrane potential. A Na+ channel blocker, to be identified, is added to the well and a stimulating current is passed through the cell in an amount sufficient to generate an action potential before and after the addition of the Na+ channel blocker. Thereafter, a change in cell membrane potential is optically measured, the abstract states.
Applera has been awarded US Patent No. 6,991,928, "Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof."
Inventors listed on the patent are Ming-Hui Wei, Shiaoping Zhu, Trevor Woodage, Valentina De Francesco, and Ellen Beasley.
According to its abstract, the patent protects amino acid sequences of peptides that are encoded by genes within the human genome, in particular kinase peptides. The patent specifically protects isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides, the abstract states.
Molecular Devices has been awarded US Patent No. 6,992,761, "Broad range light detection system."
Inventors listed on the patent are Douglas Modlin, David Stumbo, Rick Stellmacher, Jonathan Petersen, and Todd French.
According to its abstract, the patent protects broad-range light-detection systems, including components and methods of use thereof. These systems may include apparatus and methods for detecting light with increased speed and/or detection efficiency, particularly in applications involving repeated analysis of the same sample and/or successive analysis of different samples, and particularly when the sample or samples have a wide range of light intensities. These systems also may include apparatus and methods for detecting light with increased accuracy over a broad range of intensities. These systems also may include apparatus and methods for automatically scaling detection range to improve detection based on the intensity of the detected light, the abstract states.