Aclara Biosciences has been awarded four U.S. patents relating to its eTag nanofluidics technology.
U.S. Patent No. 6,673,550, "Electrophoretic tag reagents comprising fluorescent compounds," covers electrophoretic probes comprising fluorescent groups as detection groups and mobility modifiers for the multiplexed detection of the binding of, or interaction between, one or more ligands and target antiligands.
U.S. Patent No. 6,682,887, "Detection using degradation of a tagged sequence," provides methods and compositions for detecting DNA sequences, particularly single nucleotide polymorphisms, using a pair of nucleotide sequences, a primer and a SNP detection sequence, where the SNP detection sequence binds downstream from the primer to the target DNA in the direction of the primer extension.
U.S. Patent No. 6,685,813, "Tandem isotachophoresis/zone electrophoresis method and system," describes a method of separating components having a given negative or positive charge and contained in a sample.
U.S. Patent No. 6,686,152, "Methods employing oligonucleotide-binding e-tag probes," covers methods for the multiplexed detection of known, selected nucleotide target sequences. The methods include the use of electrophoretic tag probes or e-tag probes, comprising a detection region and a mobility-defining region called the mobility modifier, both linked to a target-binding moiety.
Cellomics has received U.S. Patent No. 6,716,588, "System for cell-based screening." The patent covers automated systems, methods, screens, and software for the analysis of cell spreading. The invention involves providing cells containing fluorescent reporter molecules in an array of locations, contacting the cells with a test stimulus, acquiring images from the cells, and automatically calculating one or more morphological features that provide a measure of cell spreading.
E.I. du Pont de Nemours and Company has been issued U.S. Patent No. 6,716,582, "Cellular arrays for the identification of altered gene expression." The patent relates to the generation and use of a cellular array in combination with other genome-registered arrays for the determination of gene function and/or perturbation mode of action. Each cellular array consists of a number of microbial strains, and each strain comprises one reporter gene fusion made up of a gene or gene fragment operably linked to a reporter gene. Each gene or gene fragment has been "registered" or mapped to a specific location in the genome of the organism. The genome-registered collection may be used to determine alterations in gene expression under a variety of conditions, are amenable to rapid assay, and may be used to confirm, correct or augment data generated from DNA microarray technology.
SurroMed has been awarded U.S. Patent No. 6,687,395, "System for microvolume laser scanning cytometry." The patent covers an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. It includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.
Honeywell International has received U.S. Patent No. 6,700,130, "Optical detection system for flow cytometry." The patent describes an optical detection system for flow cytometry that uses two or more light sources positioned laterally at different distances from a central axis of a flow stream for providing light through different parts of the flow stream. One or more lenses are used to focus the light from the two or more light sources through the flow stream and onto a common focal point or region on the opposite side of the flow stream. One or more light detectors are then placed at, near, or around the common focal point or region. A processor or the like receives at least one output signal from the one or more light detectors to analyze and determine selected characteristics of the flow stream.