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NEW YORK – University of California, Los Angeles researchers have modified a circulating tumor cell (CTC) purification system to help detect early-stage hepatocellular carcinoma (HCC) in patients by identifying biomarkers in tumor-derived extracellular vesicles (EVs).

The two-step process, coined "EV Click Chip," involves collecting and purifying extracellular vesicles from a patient's blood sample before performing reverse-transcription Droplet Digital PCR (RT-ddPCR) on the EVs to identify early-stage HCC biomarkers.

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