Skip to main content
Premium Trial:

Request an Annual Quote

Strata Oncology, Pfizer Partner to Explore New Biomarker Indications for FDA-Approved Drugs

NEW YORK – Strata Oncology on Tuesday said it will conduct a study to evaluate new biomarker-defined indications for targeted therapies and immunotherapies already approved by the US Food and Drug Administration.

So far, Pfizer has partnered with Strata to provide drugs to advanced solid tumor patients in four arms of the platform trial, dubbed Strata Precision Indications for Approved Therapies, or Strata PATH. The Ann Arbor, Michigan-based molecular profiling firm expects other pharmaceutical companies will join after the study is launched. The company doesn't have an official launch date but expects to begin the trial soon.

In order to join the study, patients must have exhausted standard lines of therapy and have biomarker profiles that match to specific treatment arms when assessed by the 429-gene StrataNGS test. Patients cannot have previously received a drug in the same class as the treatment they match to.

Platform trials are increasingly being used to discover novel, biomarker-defined indications of approved cancer therapies. The American Society of Clinical Oncology's TAPUR trial is one such effort and has reported out several positive arms. The WIN Consortium used genetic sequencing and transcriptomics to match patients to treatment arms in the WINTHER trial.

Strata is drawing on information in its clinical-molecular database to identify the new biomarker-informed, pan-tumor drug indications it is exploring in its platform trial. The database includes cancer patients' genomic and transcriptomic profiles, as well as their treatment outcomes.

Pfizer is the first pharma partner to contribute drugs for this study, but Strata has not disclosed which drugs will be evaluated in the trial, nor the biomarker-defined indications of interest. "Using Strata's data-driven approach, the PATH study will provide an opportunity to explore whether it's possible for patients to benefit from precision therapies that are approved in other selected cancer types," Chris Boshoff, chief development office for Pfizer Oncology, said in a statement.

This year, Strata also began a study of its investigational liquid biopsy test for disease monitoring and assessing treatment response.

The Scan

Highly Similar

Researchers have uncovered bat viruses that are highly similar to SARS-CoV-2, according to Nature News.

Gain of Oversight

According to the Wall Street Journal, the Biden Administration is considering greater oversight of gain-of-function research.

Lasker for mRNA Vaccine Work

The Scientist reports that researchers whose work enabled the development of mRNA-based vaccines are among this year's Lasker Award winners

PLOS Papers on Causal Variant Mapping, Ancient Salmonella, ALK Fusion Test for NSCLC

In PLOS this week: MsCAVIAR approach to map causal variants, analysis of ancient Salmonella, and more.