Sequencing Study Sees Frequent RAS-MAPK Mutations at Neuroblastoma Relapse | GenomeWeb

NEW YORK (GenomeWeb) – In Nature Genetics, an international team led by investigators in the US, Netherlands, and France pinpointed a role for the RAS-MAPK signaling pathway in neuroblastoma relapse.

The researchers analyzed whole-genome sequencing data on diagnostic tumors, relapse tumors, and normal samples from nearly two-dozen individuals with neuroblastoma — a peripheral sympathetic nervous system cancer involving tumors in the abdomen, chest, or elsewhere.

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