NEW YORK (GenomeWeb) – Using a new statistical analysis approach, researchers have uncovered thousands of rare somatic variants associated with cancer.

Rather than using a gene-centric approach to tease out driver mutations from within cancer sequencing data, researchers from the University of Maryland used a model that examines protein domain families. In that way, they identified protein domains — which they called "oncodomains" — that were shared across different proteins that are frequently mutated within cancer samples.

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