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NEW YORK – A new proteogenomic analysis of breast cancer samples points to tumor subtypes that may be vulnerable to immune checkpoint or other therapies. 

By combining tumor DNA and RNA sequencing with mass spectrometry-based proteomics, researchers from the Clinical Proteomic Tumor Analysis Consortium aimed to deeply profile tumors to identify modifications that could suggest potential treatment approaches.

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The Phosphoinositide 3-Kinase (PI3K) pathway is one of the most frequently altered pathways in human cancer and plays a significant role in disease progression and resistance to endocrine therapy.

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Diverse components of the UC Davis campus have been mobilized to deploy HTP testing to provide a safe working environment and keep the pandemic under control.