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NEW YORK (GenomeWeb) – Researchers have linked inherited germline mutations in six cancer predisposition genes to pancreatic cancer risk.

A team led by the Mayo Clinic's Fergus Couch examined the coding regions of 21 cancer-predisposing genes like TP53, BRCA1, or ATM in more than 3,000 pancreatic cancer patients, to search for mutations. Epidemiological studies have suggested that between 10 percent and 20 percent of pancreatic cancers have an inherited aspect, he and his colleagues noted.

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