Mobile Elements May Drive Esophageal Cancer, Researchers Say | GenomeWeb

NEW YORK (GenomeWeb) – Jumping genes are more common in esophageal cancers than previously thought and may have a role in disease development, according to a University of Cambridge research team.

While analyzing whole-genome paired-end sequencing data from esophageal tumors as part of the International Cancer Genome Consortium, the team noticed a class of rearrangements that intrigued them. As several tumors had rearrangement breakpoints at about the same spot, the team suspected that these apparent rearrangements might actually be mobile element insertions.

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