Skip to main content
Premium Trial:

Request an Annual Quote

Exai Bio Raises $67.5M in Series A Round for Liquid Biopsy Early Cancer Detection Platform

NEW YORK Liquid biopsy test developer Exai Bio said Thursday that it has closed a $67.5 million Series A financing round to accelerate development of an RNA-based liquid biopsy platform for early cancer detection.

Life sciences and technology investors Section 32 and Casdin Capital led the financing round, with participation from Two Sigma Ventures.

San Francisco-based Exai Bio said its testing platform enables early diagnosis of cancer from blood samples to inform personalized treatments.

The platform uses artificial intelligence and machine learning algorithms to analyze cell-free RNA profiles, with a specific focus on orphan noncoding RNA — small RNA sequences not seen in normal tissue that are abundant in tumors.

Exai Bio holds an exclusive license for the development and commercialization of its testing platform from the University of California, San Francisco Innovation Ventures’ Office of Technology Management & Advancement.

The technology has been used in multiple studies, including the I-SPY 2 trial, conducted in collaboration with UCSF, which is designed to improve outcomes in individuals with high-risk breast cancer, Exai Bio said.

Hani Goodarzi, cofounder and scientific adviser for the firm, presented data from I-SPY 2 on Thursday at the San Antonio Breast Cancer Symposium in San Antonio, Texas.

"The data in the neoadjuvant breast cancer setting is significant, as early-stage breast cancer has been a difficult target for ctDNA-based liquid biopsy approaches," Goodarzi said in a statement.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.