Skip to main content
Premium Trial:

Request an Annual Quote

Epic Sciences, Biosplice Therapeutics Partner on Multiomic Profiling for Cancer Trials

NEW YORK – Biosplice Therapeutics is partnering with Epic Sciences to incorporate multiomic profiling into Biosplice's clinical oncology programs, the companies said on Thursday.

As part of the collaboration, Biosplice plans to use Epic's liquid biopsy platform to characterize drug activity and patient response for its Cirtuvivint (SM08502) investigative drug in two clinical trials.

Cirtuvivint, one of Biosplice's lead therapeutic candidates, is a small molecule oral inhibitor of the CDC-like kinase and dual-specificity tyrosine regulated kinase family. The two ongoing trials explore its safety, tolerability, and primary efficacy in several solid tumor indications.

Financial details of the collaboration were not disclosed.

Epic's liquid biopsy platform "provides the opportunity to characterize late-stage cancer patients both phenotypically and genotypically," Darrin Beaupre, chief medical officer at Biosplice Therapeutics, said in a statement. "This is a critical part of our clinical trial as it allows us to better understand both the underlying biology and therapeutic response of the patient."

Epic has ample experience characterizing cancers. Earlier this month, the company said it is preparing to launch its DefineMBC lab-developed test, aimed at comprehensively profiling metastatic breast cancers when a tissue biopsy is unavailable.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.