risk stratification ACMG Workgroup Addresses Cancer Risk Variability With CHEK2 Alterations in Practice Resource The workgroup reviewed the available evidence and recommended clinicians manage patients based on the type of variants they have along with family history and other factors. Pacific Edge Ramps up Clinical Utility Studies, Commercial Efforts Behind Bladder Cancer Test Premium The New Zealand-based diagnostics firm is hoping the coming year will be a tipping point toward new guideline inclusion and broader adoption. Model Predicts Blood Cancer Progression Risk for Clonal Hematopoiesis Patients Premium A score developed using UK Biobank data can identify patients at high and low risk for blood cancer progression and is starting to be used at Dana-Farber Cancer Institute. COPD Risk Loci Uncovered With GWAS, Machine Learning-Based Phenotyping Using a machine learning model for distinguishing individuals with or without COPD, researchers identified dozens of new and known risk loci. Inflammatory Gene Expression Score IDs High-Risk AML Patients Premium Unique inflammation-associated gene expression signatures in adult and pediatric AML patients may speed risk stratification and treatment decisions. May 20, 2022 Palmetto Finalizes Positive LCD for Prostate Cancer Risk Tests Apr 5, 2022 Polygenic Transcriptome Risk Scores for COPD Show Improved Cross-Ancestry Portability Feb 22, 2022 Arcensus Hopes DTC Testing Will Help Genome Sequencing Become First-Line Rare Disease Diagnostic Premium Dec 10, 2021 Researchers ID Genomic Signature to Risk Stratify Patients With Precancerous Breast Lesions Oct 27, 2021 Polygenic Risk Scores Edge Toward Clinic, Though Disease Prediction Utility Questions Linger Premium Sep 28, 2021 Genetic Technologies, WashU Team up to Study Breast Cancer Risk in Woman of African Descent Sep 16, 2021 Polygenic Risk Scores for Breast, Prostate Cancer Adaptable for Cross-Ancestry Use, Study Shows Aug 27, 2021 Oncocyte Launches Prospective Registry to Drive DetermaRx Adoption, Improve Coverage Premium Jul 28, 2021 Sequencing Firm Phosphorus Tests Limits of Comprehensive Consumer Genomics With GeneCompass Premium Jul 22, 2021 Volpara Adding Invitae Genetic Test Ordering to Breast Risk Software Platform Jul 15, 2021 Glaucoma Polygenic Risk Score Appears Similarly Informative to Monogenic Risk Assessment Jun 30, 2021 Recuro Health Enters Genomics Market With MyLegacy Purchase from Cleveland Clinic Premium Jun 7, 2021 Lynparza Benefit in Early BRCA-Mutated Breast Cancer Reignites Universal Genetic Testing Discussion Premium Jan 26, 2021 BC Platforms, Finnish Researchers, Japan's Riken Partner on COVID-19 Risk Assessment Oct 26, 2020 GoodCell Raises $17.9M for Analytics Technology, Personal Biobanking Sep 9, 2020 Machine Learning Tool Enables Analysis of Complex, Polygenic Phenotypes With Epistastic Interactions Premium Aug 13, 2020 Weill Cornell Using $1.5M NIH Grant to Predict Severity of COVID-19 Cases Premium Jul 1, 2020 NIH Allocates $75M to Create eMERGE Risk Assessment Network Jun 18, 2020 After DNA-10K, NorthShore Looks to Expand Genomics Integration Into Primary Care Premium Jun 11, 2020 Diversity Problem Hinders Adoption of Polygenic Risk Scores, According to ESHG Panel Load More Breaking News SARS-CoV-2 Variants of Concerns Evolved to Modify Host Immune Response, Multiomics Study Shows People in the News at GA4GH, Mercy BioAnalytics, Deepcell, One Biosciences New Products Posted to GenomeWeb: Clinical Microbiomics, Integra Biosciences, DNAstack, Bruker Angolan Namib Desert Population Analysis Uncovers New Ancestry Group With Deep Divergence Cedars-Sinai Sets Up $25M Single Cell Precision Medicine Center The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.