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Though the test is already commercially available, the firm met with the FDA last year to discuss plans for a randomized controlled trial to support regulatory approval.

MSK researchers showed that high TMB may be associated with improved survival across tumor types, but the cut-offs for high and low status will vary based on histology.

Data from the GUIDED study will be central to commercial payor discussions, a Medicare LCD reconsideration request, and eventually expansion into the primary care market.

The investment bank upgraded the company's stock to an Outperform rating from Market Perform but lowered its price target to $37 per share.

Publication of He Jiankui's work on gene-edited infants would raise ethical concerns for journals, Wired and others report.

See What They Said

Following a pilot project, Genome Biology is to adopt a transparent peer review process at the beginning of 2019.

Room for Improvement

Indiana University School of Medicine's Aaron Carroll discusses the flaws and ways to improve peer review at the New York Times.

One of the largest repositories of molecular brain cancer data in the world, the enhanced REMBRANDT is more comprehensive than an earlier NCI-hosted version.

A pair of researchers has found that retracted papers are often still cited and call for them to be harder to access, Retraction Watch reports.

Just Skip that Step

The Economist writes that an increasing number of scientific journals don't do peer review.

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Bloomberg reports that the DNA-for-cash deal reported in Kentucky might be a more widespread scam.

St. Jude Children's Research Hospital scientists have treated infants with X-linked severe combined immunodeficiency using gene therapy in an early phase study.

St. Louis Public Radio reports that some African Americans are turning to DNA ancestry testing to help guide genealogical searches.

In Nature this week: a genomic analysis of the snailfish Pseudoliparis swirei, ancient DNA analysis gives insight into the introduction of farming to England, and more.