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The method, published in Science, pairs in situ sequencing with NGS using barcodes to provide spatial information on DNA sequences inside tissues.
The methods, both published in Nature Biotechnology this week, result in completely phased haplotypes, without the need for sequencing parental samples.
Developed by researchers at Yale University, the method, called deterministic barcoding in tissue sequencing, can map thousands of genes at 10 micron resolution.
PLOS is piloting a new model under which research institutions pay a flat fee for its researchers to publish in its journals, Science reports.
Nature News reports that a new initiative aims to make the abstracts of scientific papers accessible at a central site.
The Lancet has made changes to its peer-review process in response to its recent retraction of a COVID-19-related paper, Science reports.
An international team of researchers put nine immune cell sequencing methods head to head, including RNA-based and DNA-based ones, using the same T-cell sample.
By employing distributed computational resources and a novel algorithm, the VariantSpark technology is able to process a trillion data points in 15 hours.
Labs are finding cheaper, higher-throughput ways to determine the inflection points in gene expression within a particular cell.
Two companies offering droplet-based single-cell RNA sequencing sample prep, 10x Genomics and 1Cellbio, have launched dual-indexed library preparation products.
Politico notes that the Biden Administration has not yet nominated a permanent Food and Drug Administration commissioner.
Anthony Fauci also informed the World Health Organization executive board that the US would be joining the COVAX initiative, according to CNBC.
A new preprint suggests some SARS-CoV-2 variants could affect the effectiveness of current vaccines, the Associated Press reports.
In Nature this week: Australian lungfish provides details on the movement of vertebrate life from water to land, and more.