peer-reviewed publication MIT Researchers Devise Oligo Barcode-Based 'File System' for DNA Data Storage Premium The researchers have applied for a patent on their technology and have formed a startup, Cache DNA, to develop a low-cost platform for DNA storage and retrieval. Global Subway Metagenomics Study Reveals Cities' Microbial Fingerprints The study found more than 10,000 viruses and hundreds of bacteria not present in any reference database, along with other novel genomic features. New Algorithms Enable Direct Nanopore-Based Detection of Additional RNA Modifications Premium The method was used to analyze two epigenetic modification types that were previously undetectable with Oxford Nanopore sequencing. Long-Read Genome Assemblies Have 'Blind Spots' for Structural Variant Detection Premium Researchers comparing structural variant detection using short- and long-read technologies said assembly-based methods can provide added value, despite missing certain CNVs. New Method Provides NGS-Based Readout of Glycan Levels in Single Cells Premium SUGAR-seq, a single-cell method developed by researchers in Australia, is a first step towards analyzing differences in glycosylation in various cell types. Feb 1, 2021 Expansion Sequencing Improves on Church Lab's In Situ Transcriptomics Method Premium Jan 11, 2021 Broad Institute, MIT Researchers Probe Genome Structure With New In Situ DNA Sequencing Method Premium Dec 8, 2020 New Methods Enable Phased Human Genome Assemblies Without Parental Data Premium Nov 17, 2020 New NGS-Based Tissue Analysis Method Offers Spatial Detail on Transcriptome, Proteins Premium Sep 9, 2020 Adaptive Biotechnologies, Takara Bio T Cell Receptor Sequencing Methods Rank High in Benchmarking Study Premium Sep 9, 2020 Machine Learning Tool Enables Analysis of Complex, Polygenic Phenotypes With Epistastic Interactions Premium Aug 31, 2020 New Methods Boost Scale of Single-Cell Gene Expression Dynamics Studies Premium Jul 30, 2020 Double-Barcoded Single-Cell Library Prep Solves Index-Hopping Issues, Lowers Sequencing Costs Premium Jun 15, 2020 Genome In a Bottle Consortium Releases Structural Variant Calling Benchmark Data Premium Jun 11, 2020 Avida Biomed Developing Hybridization-Based Methylation Sequencing Panels for Cancer Dx Premium Jun 2, 2020 10x Genomics, Collaborators Develop Targeted Single-Cell Gene Expression Methods Premium Apr 27, 2020 Rockefeller University, Cerevance Pursue Pooled Nuclei Sequencing to Target Brain Cell Types Premium Apr 23, 2020 Harvard Spinout 1CellBio Seeks Ideas for Applications of Targeted Single-Cell Tech Premium Mar 26, 2020 GigaMune Hopes to Offer TCR Screens to Pharmas While Scrambling to Keep Expression Libraries Alive Premium Mar 5, 2020 New Sepsis Test Uses Nanopore Sequencing to Detect Pathogens From Cell-Free DNA Premium Feb 10, 2020 Nanopore Sequencing-Based Mapping Methods Reveal Open Chromatin, Methylation Patterns Premium Jan 13, 2020 Integrated Single-Cell RNA-Seq, Array Spatial Transcriptomics Analysis Puts Cells Into Context Dec 5, 2019 High-Throughput Single-Cell Transcriptomics Assay Facilitates Compound Screens Premium Dec 3, 2019 SciLifeLab Researchers Develop Multiplexed Library Prep Method for FFPE Samples Premium Aug 15, 2019 HiFiBio Bets on Single-Cell Methods to Boost Drug Discovery Premium Load More Breaking News Dilated Cardiomyopathy Gene Mutations Point to Possible Therapeutic Strategy Ginkgo Bioworks Acquires Massachusetts COVID-19 Testing Firm Mainz Biomed Taps DCN Dx to Aid European Study of Enhanced ColoAlert Assay Parse Biosciences Partners With Research Instruments for Southeast Asia Distribution Thermo Fisher, Oncocyte Ink Development, Comarketing Deal for Cancer IVDs Yourgene Health Enters Three-Year £5M Term Loan Facility The Scan And a Fourth? A fourth dose of the Pfizer-BioNTech SARS-CoV-2 vaccine in an Israeli study increased antibody levels but did not prevent Omicron variant infections, according to the Financial Times. For Better Science Software A virtual institute funded by former Google CEO Eric Schmidt's philanthropy aims to lure software engineers to academia, Science reports. Recommendation Explanations The New York Times writes that the US Centers for Disease Control and Prevention is straining to both make and explain decisions based on limited information. Genome Research Papers on De Novo Mutation Rates, Polyploid Genotyping, Oncogene Epigenomic Translocation In Genome Research this week: de novo mutations rates in hemoglobin subunits, analysis of variant calling methods for polyploid plants, and more.