peer-reviewed publication Researchers Go Beyond Gene Variant Analysis With Nascent Pangenome-Based Methods Premium New studies suggest many methods that map NGS reads to a reference can be improved using a graph-based reference genome rather than a linear one. New Enzymatic Approach Enables Transcriptome-Wide N6-Methyladenosine Profiling, Quantification Premium The method, dubbed eTAM-seq, offers scientists a new way to study m6A modifications in mRNA at a high resolution while lowering the sample input requirement. New MGH Technology Taps Microscopy for Single-Cell Sequencing in Spatial Context Premium Image-seq deploys in vivo or in situ imaging to isolate cells from specific tissue locations for single-cell sequencing. Stanford Method Enables Targeted Profiling of Human Extrachromosomal DNA Premium Using CRISPR-CATCH, researchers can enrich and study megabase-sized ecDNA from human cancer cells, gaining insights into their heterogeneity and epigenome. New Direct Nanopore Sequencing Method Expands Toolkit for RNA Structure Profiling Premium SMS-seq combines structural probing with direct RNA nanopore sequencing, offering researchers a new way to study RNA structure at the single-molecule level. Oct 18, 2022 AMP, CAP Release Guidelines for Use of In Silico Approaches for Validating NGS Data Pipelines Oct 12, 2022 Harvard Researchers Publish Light-Activated Spatial Transcriptomics Method Premium Oct 7, 2022 EEL FISH Study Shows Proof of Concept for Spatial Method Licensed to Rebus Biosystems Premium Sep 30, 2022 New Single-Cell RNA-seq Method Enables Transcriptomic Profiling of Live Cells Premium Sep 23, 2022 Researchers Demonstrate Multiplex Codon Editing in the Human Genome Premium Sep 21, 2022 Improved Nanopore Basecalling Models Help Reduce Sequencing Errors in Telomeres Premium Sep 8, 2022 New CRISPR-Based DNA Recorder Tracks Order of Transcriptional Events in Bacterial Cells Premium Sep 1, 2022 Nanopore Sequencing Assay Enables Rapid Fetal Aneuploidy Detection Premium Aug 24, 2022 New Sequencing Method Tackles Environmental DNA Contamination for Cell-Free DNA Samples Premium Aug 12, 2022 Optical Genome Mapping Gains Momentum for Clinical Applications in Hematologic Disorders Premium Aug 3, 2022 Long-Read Sequencing Reveals Tens of Thousands of Novel Transcripts Across Different Human Tissues Premium Jul 21, 2022 New Nanopore Sequencing Chemistry Enables Assembly of Near-Finished Bacterial Genomes Premium Jul 1, 2022 New Single-Cell 'Total' RNA-seq Method Promises More Comprehensive Transcriptome View Premium Jun 22, 2022 Spatial, Single-Cell Transcriptomics Data Integration Algorithms Go Head-to-Head in Study Premium Feb 24, 2022 Researchers Look to New Sequencing Methods to Settle Debate Over 6mA Modifications in Humans Premium Feb 1, 2022 Roswell Biotechnologies Provides Details on Molecular Electronics Device in Proof-of-Concept Study Premium Jun 11, 2021 MIT Researchers Devise Oligo Barcode-Based 'File System' for DNA Data Storage Premium May 28, 2021 Global Subway Metagenomics Study Reveals Cities' Microbial Fingerprints May 26, 2021 New Algorithms Enable Direct Nanopore-Based Detection of Additional RNA Modifications Premium Apr 8, 2021 Long-Read Genome Assemblies Have 'Blind Spots' for Structural Variant Detection Premium Load More Breaking News Cancer Prognoses Informed by Module-Based Approach, Study Finds People in the News at Illumina, Centogene, BioSkryb New Products Posted to GenomeWeb: Bio-Rad, BD, Analytik Jena, BioMérieux Genetic Technologies to Raise A$5M in Direct Stock Offering In Brief This Week: SD Biosensors, Meridian, Oncocyte, Opko Health, GeneDx, More The Scan Study Reveals New Details About Genetics of Major Cause of Female Infertility Researchers in Nature Medicine conducted a whole-exome sequencing study of mote than a thousand patients with premature ovarian insufficiency. Circulating Tumor DNA Shows Potential as Biomarker in Rare Childhood Cancer A study in the Journal of Clinical Oncology has found that circulating tumor DNA levels in rhabdomyosarcoma may serve as a biomarker for prognosis. Study Recommends Cancer Screening for Dogs Beginning Age Seven, Depending on Breed PetDx researchers report in PLOS One that annual cancer screening for dogs should begin by age seven. White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.