The methods, both published in Nature Biotechnology this week, result in completely phased haplotypes, without the need for sequencing parental samples.
Developed by researchers at Yale University, the method, called deterministic barcoding in tissue sequencing, can map thousands of genes at 10 micron resolution.
An international team of researchers put nine immune cell sequencing methods head to head, including RNA-based and DNA-based ones, using the same T-cell sample.
By employing distributed computational resources and a novel algorithm, the VariantSpark technology is able to process a trillion data points in 15 hours.
